Maybe the gods are jealous of Naruto's ability to inspire people. In this fanfic, they could use their divine powers to make it seem like Naruto has committed heinous crimes. His village would turn on him, and he'd be on the run. Along the way, he might discover some ancient power that can counter the gods' treachery and use it to clear his name and get revenge on those who wronged him.
Obviously, the gods themselves would be the main antagonists. They have the power to manipulate Naruto's world and his fate. They could be some sort of ancient deities who have been watching over the ninja world from afar and now feel the need to interfere.
Initially, Naruto would be heartbroken. His friends and his village mean everything to him, and the thought that the gods, who are supposed to be just, have turned against him would be a huge blow. However, he wouldn't give up. He would use his determination and his unwavering belief in himself. He might start looking for allies among those who are also disillusioned with the gods or who believe in his innocence.
One possible plot could be that the gods, seeing Naruto's growing power as a threat, decide to turn the world against him. They might manipulate events to make it seem like Naruto has committed unforgivable crimes. For example, they could cause false memories in people's minds. Naruto would then have to fight not only against the physical enemies but also against the false accusations and the loss of trust from his friends.
Well, it could be that Naruto discovers the gods have been using him all along for some dark purpose, like to start a war between different ninja clans. Maybe they promised him power in the beginning but then turned on him when he started to question their motives.
Another possibility is that there is a false god or a demon that has influenced the true gods to betray Naruto. This false entity could be the real mastermind behind the whole situation. It wants to use Naruto's downfall to gain more power or to bring chaos to the ninja world. So Naruto not only has to deal with the betrayed by the gods part but also has to uncover the true source of this conspiracy which is this false god or demon.
One possible scenario in such a fanfic could be that Naruto is betrayed by his new comrades in the DxD world. Maybe they misunderstand his motives or are jealous of his power. For example, they might think he's using his abilities for his own gain rather than the common good.
Naruto would probably be extremely hurt. He has always considered Hinata a friend and perhaps more. Betrayal from her would be a huge blow to his trusting nature. He might initially be in denial, not wanting to believe that Hinata could do such a thing.
It could be Zabuza. He might pretend to be on Naruto's side at first during the Wave events and then betray him when Naruto least expects it. Zabuza is a mercenary and his loyalty can be easily swayed.
Naruto would be deeply hurt. He would probably feel a mix of anger and sadness. At first, he might try to reason with Tsunade, to find out why she betrayed him.