The reactions would vary greatly. The older characters like Kakashi might just raise an eyebrow and go along with it if it serves a purpose. But the younger, more impressionable characters like Konohamaru might look up to Naruto even more, seeing him as someone who can be so adaptable. And some of the more traditional characters might be a bit scandalized at first, but as they see Naruto's intentions, they could come around.
Iruka would be concerned at first, thinking if Naruto is in some sort of trouble. But once he realizes it's just a situation, he would be more accepting. As for the other ninja in the village, some might be envious of Naruto's ability to pull off the girl look, while others might be confused and keep their distance until they understand what's going on.
If Naruto becomes unstable, Sasuke might be one of the first to be affected. Since they have a deep bond, Sasuke would feel responsible to bring Naruto back to his normal state. Sakura, too, would be worried. She might try to use her medical ninjutsu skills to see if there's a physical cause for Naruto's instability and then try to find a solution.
When Naruto dresses up as a girl, he could become more observant of social norms for females. He notices how girls interact with each other and how they are treated in the village. This makes him more empathetic towards the female characters. He might start to advocate for better treatment of women in the village, using his experiences while dressed as a girl. His natural leadership qualities could then be directed towards promoting gender equality in a new and unexpected way.
It can make characters like Kakashi feel a bit annoyed. Kakashi might think Kurenai is being too overbearing and it could disrupt the normal team dynamics if he also has a role in Naruto's development.
It could make his friends worry a great deal. For example, Sasuke might be concerned about Naruto's well - being and try to reach out to him. This could lead to a new dynamic in their relationship, with Sasuke being more proactive in their friendship.
His friends would be worried. Sakura, for instance, might try to reach out to him and get him to open up. She could be constantly checking on him, bringing him food or just sitting with him in silence, hoping he'll start talking again.
The village elders would be in a state of panic. Naruto was seen as a symbol of hope and power for the village. His departure would mean a significant loss of strength and morale. The younger generation of ninja who looked up to Naruto would also be greatly affected. They might lose their motivation and start to question the values of the village.
The other characters in the pack might initially be very protective of Seth. They could be worried that the girl's past abuse might make her unpredictable or a liability. For example, they might be cautious about sharing pack secrets with her at first. However, if Seth is able to show them that she's trustworthy and on the path to healing, they might start to accept her more. On the other hand, there could be antagonists in the story who see Seth's connection to the girl as a weakness and try to use it against him.
If Naruto has a physical disability like a broken arm that doesn't heal properly in fanfiction, his friends like Sasuke and Sakura would need to step in and help him more. Sasuke might be more protective, which could change their dynamic from a competitive one to a more collaborative one. Sakura could use her medical skills to try and find a way to heal him, which would bring them closer. His relationship with his teachers, like Kakashi, would also change as they'd have to adjust their training methods.
Well, Naruto's personality can change in multiple ways. When he's dressed as a girl, he might become more cautious. He realizes that as a girl, he may not have the same physical strength advantage he usually has. So, he starts relying more on his wits and charm. He also might develop a different sense of humor, perhaps more gentle and sly, to fit his new identity. Additionally, he could become more protective of other girls around him, seeing things from their perspective now.