The Akatsuki as a whole could be the opponents. Imagine Naruto facing multiple Akatsuki members at once in a fight. The combined threat of their different powers and their goals of capturing the tailed beasts could be overwhelming for Naruto. They might use underhanded tactics, like threatening to kill captives or using mind - control techniques on Naruto's friends. All of these things could make Naruto go insane as he battles against them, trying to protect what he loves.
Well, there are several factors. Firstly, a monotonous environment with no variety or novelty can do it. Secondly, if she has no goals or passions to pursue, it can lead to boredom-induced insanity. Also, a lack of intellectual stimulation might play a role.
It's hard to pinpoint exactly where Gojo is at any given time in the manga. His whereabouts change as the story progresses and different scenarios unfold. It could be in a supernatural realm, a mission site, or interacting with other characters.