The Matrix has no connection to a comic book. It's a standalone creation that has become a cult classic in its own right. The complex storyline and visually stunning effects were crafted specifically for the film and not adapted from a pre-existing comic book source.
It depends on what you mean. If you're referring to a specific comic you have in mind, more details would be needed to determine if it's the one. But if you're asking in a general sense, it's not clear without more context.