One possible theme could be self - discovery. If Lisa is the main character, she may be on a journey to find out who she really is in 'the first story'.
I'm not sure specifically which 'lisa the first story' you are referring to. It could be a very unique and personal story, or perhaps a story within a specific community or family. Maybe it's about a girl named Lisa and her first adventure, like her first day at a new school or her first encounter with a magical creature.
Another theory is that it might be a composite of several different women. However, historical evidence mostly points towards Lisa Gherardini. She lived in the same time and place as Leonardo da Vinci, and the connection through her husband's commission is a significant factor.
Lisa is the main character in this story. She is likely someone who has been struggling with obesity and her story is being told in the context of 'watch my 600 lb life'.
I'm not sure who Lisa Mcvey is exactly just from this title. She could be an ordinary person with an extraordinary story, or she might be someone known in a specific community.