In the comics, Spider-Gwen is not depicted as a trans character. Her character identity is defined by other aspects of the story and her superhero persona.
Gwen Stacy is not trans in the comics. The character has been presented in a conventional gender role throughout the comic series. There have been no storylines suggesting otherwise.
[The characters in the game include the supporting character, Griffin, whose identity and origin are unknown. He has signed a contract with William.] The male lead was William Blake, who was slightly afraid of society. The female lead was Gwen Stacy, who was Spiderman. The male lead was Ralph Ellison, the leader of the Raven Gang. The female lead was Wicks.
"Syndicate of Spider Gwen" by Noktunar. It is a light novel/derivative doujinshi novel with group portraits, special abilities, upgrade flow, and comics elements. It is completed and can be enjoyed without worry.
William received a mysterious letter asking him to investigate the death of Peter Parker. So he brought his partner Griffin from the countryside to New York.
However, New York did not seem to be calm. The underground world was surging with the imprisonment of Jin Bing, and the spider woman Gwen Stacy was fighting with various aptitude users in the surface world.
"Lady Shadow greets you. I'm Nightingale, the new doctor in this city."
I hope you will like this book.