In the comics, Spider-Gwen is not depicted as a trans character. Her character identity is defined by other aspects of the story and her superhero persona.
The age of Spider-Gwen in the comics is not set in stone. However, she is commonly presented as a teenager, approximately 17 or 18 years old, as she navigates her superhero adventures while dealing with typical teenage challenges.
The first Spider-Gwen comic is Edge of Spider-Verse #2. It brought a new and exciting perspective to the Spider-Man universe, featuring a female version of the web-slinger with her own set of challenges and storylines.