Gwen Stacy is not trans in the comics. The character has been presented in a conventional gender role throughout the comic series. There have been no storylines suggesting otherwise.
In the comics, Spider-Gwen is not depicted as a trans character. Her character identity is defined by other aspects of the story and her superhero persona.
There was a recommended novel about transmigrating cells and cultivating immortality called "Cell Cultivation". This novel was a Xianxia/Cultivation novel, which included transmigration, prehistoric, interstellar, and technological cultivation elements. You can read this novel on Qidian Chinese website. The author is China's Jiao Zi, Giant Panda.