They can be related in various ways. Sometimes comics inspire animations, and animations might bring the comic's characters and stories to life in a more dynamic form.
The appeal of toi comic strips lies in their creativity and the way they can transport you to different worlds. The characters are often well-developed, and the plots keep you hooked.
Well, Annoying Orange is mainly a web series and not typically associated with manga. Maybe there could be some fan-made crossover art or comics, but that's not an official connection.
Halloween witch cartoons often have spooky settings, magical powers for the witches, and lots of dark colors. They might show witches flying on broomsticks or brewing potions.