The main antagonist could be a mysterious figure who has the ability to create illusions in both the minds of the Metro Last Light characters and Naruto. This figure uses these illusions to drive a wedge between Naruto and his new allies, causing chaos and mistrust. It could be an entity that feeds on negative emotions and wants to keep the metro in a state of despair.
Maybe the main antagonist is a corrupted military leader in the Metro Last Light world. He sees Naruto as a threat to his power and control. He starts a war against Naruto and the people who side with him. He uses his military resources and knowledge of the metro layout to try and defeat Naruto, much like how Orochimaru was a constant threat to Naruto in his own world.
A plot could involve a group of villains in the Metro Last Light world getting their hands on some of Naruto's chakra - based techniques. Naruto has to team up with the main characters from Metro Last Light to get these techniques back before they are misused. Along the way, Naruto discovers new aspects of his own powers while adapting to the post - apocalyptic setting of Metro Last Light.
Another possibility is that Naruto himself could be his own antagonist in a sense. His loneliness and the weight of being the last man on earth could drive him to the brink of madness. He might have to fight his own inner demons, which could be manifested as a dark version of himself that wants to give up on the world and just let it decay.
One option could be Kaguya from the Naruto universe. Her god - like powers would pose a great threat to Bayonetta. She could be trying to expand her influence into Bayonetta's world, seeing it as a new place to conquer.
It could be a dark wizard who wants to capture the nymph for her powers. He sees the nymph's connection to nature and wants to use it to gain ultimate power in the Naruto world.
It could be a rogue ninja who has also discovered a way to harness the power of Amaterasu in a corrupt way. This ninja might want to use the power to take over the ninja villages and Naruto stands in his way.
It could be an evil ninja from Naruto's world who has somehow gained the ability to control Digimon. He wants to use this power to rule over both worlds. He targets Renamon because of her connection to Naruto and tries to break their bond. He might also be after the special powers that Naruto and Renamon possess when they work together.
It could be a rogue ninja who has a vendetta against Naruto and sees Heather as a way to get to him. Maybe this ninja was once defeated by Naruto and now wants to use Heather as bait or hurt her to break Naruto's spirit.
Perhaps a rogue ninja who has learned about the mummy's existence and wants to sell it to the highest bidder. He will stop at nothing to get the mummy, even if it means fighting Naruto and causing chaos in the process.
The Akatsuki could also serve as the main antagonists. They might view Naruto and Midnight as threats to their plans. For instance, if they find out that Midnight has some knowledge or power that could disrupt their collection of tailed beasts, they would target them. Naruto and Midnight would then have to fight against the Akatsuki's various members, each with their own dangerous abilities.
It could be a powerful dark wizard from the Enchantress' world who follows her to the Naruto universe. He wants to capture the Enchantress and use her powers for his evil plans, and also sees the chakra in Naruto's world as a new source of power to conquer. He could have dark magic that can nullify ninjutsu, creating a real challenge for Naruto and the Enchantress.