Snape might be suspicious at first. He might think it's some sort of trick or part of a bigger plot. However, as he observes Hermione more closely and realizes the genuineness of her situation, his attitude could gradually change to one of reluctant assistance. He might even offer some words of wisdom, albeit in his typical sarcastic way, to help Hermione regain her strength.
He may show a rare moment of kindness. Given his own past traumas and experiences, he might empathize with Hermione on some level. He could offer her some words of wisdom or even some form of magical assistance to help her get better.
He might initially show annoyance. After all, Hermione is often seen as a know - it - all in his eyes. But his sense of justice and his underlying good nature (despite his cold exterior) would kick in. He'd untie her in a rather brusque manner, but then start to question her about how she got into this mess. Depending on her answer, he might offer some cryptic advice on how to avoid similar situations in the future.
One possible reason could be the stress from her studies. Hermione is always under a great deal of pressure to excel academically. Maybe she reached a breaking point due to the overwhelming workload. Another reason might be some kind of conflict with her friends. For example, if she had a big fight with Harry or Ron over something serious, it could leave her feeling broken.
She might be initially defensive. Hermione is a proud and independent character. So, when Snape finds out about her arm, she could be worried that he'll use it against her in some way, like taking away house points or using it as an excuse to give her extra work.
He is often very suspicious. He might immediately think it's some kind of trick by the Marauders or their descendants. He'll likely try to figure out how to use it to his advantage against those he dislikes.
Snape might initially be shocked. He's not one to show much emotion openly, but internally he could be very disturbed. He might start investigating what happened to Hermione immediately, using his skills in potions and magic to try and find a cure or at least understand the cause.
He might immediately go into a protective mode. He could use his potions knowledge to quickly make a healing draught for her. After all, Snape is very skilled in potions, and Hermione being hurt would likely trigger his instinct to help.
He might be initially startled. Snape is used to seeing Hermione as a strong - willed and confident student. So seeing her crying could catch him off - guard. But then he might quickly put on his usual cold facade and ask her curtly what's wrong.
One possible reason could be that she was attacked by some dark creatures while on a solo adventure in the Forbidden Forest. The forest is full of dangers, and Hermione, being brave and curious, might have ventured too deep and got injured by a creature like a werewolf or a giant spider.
He could be secretly worried. Snape might use his knowledge of potions and dark magic to try and find a cure or at least a way to stop the bleeding. He may also be conflicted, as his past relationship with Harry and his loyalty to different sides in the wizarding world play a role in how much he wants to help Harry.