Naruto would likely be extremely hurt emotionally. Tsunade is like a mother figure to him, and such a betrayal would shatter his trust. He might become more withdrawn and question his own worth.
On a more practical level, Naruto might face a lot of danger. Without Tsunade's support, he could be hunted by the village or by enemies who see him as vulnerable now. His access to resources and support within the village would be cut off, making it difficult for him to survive and continue his ninja journey.
He would probably be very confused at first. Naruto has always trusted Tsunade, so the betrayal would come as a huge shock.
He would probably become very distrustful. After all, if your own parents betray you, it's hard to trust anyone else. He might isolate himself from others in the village, thinking that if his parents could turn on him, anyone could.
Naruto would likely be deeply hurt. He is a character who values friendship and loyalty highly. Being betrayed by someone he might have considered an ally like Rias would be a huge blow to his emotional state.
He could also try to talk to them directly, despite the betrayal. Naruto has always believed in the power of communication and the bonds between people. He'd want to understand why they thought he was worthy of betrayal and try to convince them that they were wrong.
His reputation in the ninja world could be damaged. If Padme spreads false information or reveals his secrets, other ninja might view Naruto differently. They could see him as a liability or a threat. This could lead to him being isolated in the ninja community, and he might have to fight harder to prove himself again.
Naruto would be devastated. He has always valued his friends highly, and their betrayal would shatter his world. He would likely feel a deep sense of loneliness and confusion. His self - confidence might take a huge hit as he wonders what he did wrong. For example, he might start doubting his own worth and his ability to make good relationships.
One possible plot could be that Tsunade and Jiraiya are deceived by false information about Naruto. Maybe they are made to believe that Naruto has turned to a dark side. For example, an enemy might have created false evidence of Naruto collaborating with a powerful evil force. Tsunade, being the Hokage, and Jiraiya, Naruto's mentor, would then be forced to take actions against Naruto that seem like betrayal from Naruto's perspective.
On Tsunade's side, she would also be conflicted. Even if she has reasons for her actions, she has a bond with Naruto. She might feel guilt and regret, especially if she realizes she was misled. The village as a whole would be in turmoil. Naruto has many friends and supporters, and if they believe he was wrongly betrayed, it could lead to a split in the village, with some siding with Naruto and others with Tsunade.
Another possibility is a misunderstanding. Maybe some false information is spread about Naruto that makes Tsunade believe he has gone bad. In the world of Naruto, there are often enemies who try to create chaos by sowing seeds of distrust. Tsunade, without fully investigating, could fall for such a trick and seem to betray Naruto.
The most immediate consequence could be a rift between Naruto and the Bleach characters. They might become enemies and start fighting. For example, Ichigo and his friends could see Naruto as a threat and try to stop him.