Perhaps Sakura blames Naruto for something that's not his fault. Say there's a big incident in the fanfiction world, like a village is attacked or a friend is hurt, and Sakura wrongly thinks Naruto is responsible. She might lash out at him with angry words, and Naruto, who always tries his best to protect everyone, would be deeply hurt and might cry.
It could be that Sakura betrays Naruto's trust. For example, if Naruto entrusts Sakura with a very important secret, like something related to his family or his new power he's developing, and Sakura reveals it to their enemies or uses it against Naruto in some way, that would be a huge blow to Naruto and could lead to him crying.
Maybe Naruto discovers some dark secret about Tsunade's past that she has been trying to hide. For example, something related to her lost loved ones. Naruto, in his usual straightforward way, confronts Tsunade about it without realizing how much it would hurt her, and thus makes her cry.
One reason could be extreme emotional pain. Maybe he witnesses the death of a very close friend or loved one in the fanfiction world. This overwhelming grief could cause such a physical manifestation as crying blood.
Maybe Draco says some really mean and hurtful words to Harry. For example, he might make fun of Harry's family situation, like his parents' death or his relationship with the Dursleys. Words like that can be really cutting and could easily make Harry cry.
Perhaps there was some sort of dark influence at play. In the world of Naruto, there are often dark forces and genjutsu (illusion techniques). It's possible that Naruto was under the influence of a genjutsu that made him see Sakura as a threat, so he punched her in self - defense without realizing it was an illusion.
One possible reason could be that Sakura realizes she has different goals or values that are not compatible with being around Naruto. Maybe she discovers a new path in life that doesn't involve him, such as focusing on her own medical ninja career without Naruto's chaotic lifestyle interfering.
One possible reason could be that Peter is keeping secrets from MJ about his Spider - Man identity. In many versions, his secrecy creates misunderstandings and MJ might feel left out or betrayed, leading to her crying.
One possible reason could be a misunderstanding. Maybe Sakura said something that Naruto misinterpreted as being hurtful or dismissive of his feelings. For example, if she made a comment about his abilities in a negative way during a crucial moment, it could lead to him distancing himself.
Another reason might be Edward's overprotectiveness. He could have made a decision for Bella without consulting her first, like preventing her from seeing a friend. This kind of controlling behavior could make Bella feel frustrated and end up in tears.
One possible reason could be that she might have underestimated Naruto in the past. She often belittled his abilities and dreams, but as she grew and realized his true strength and determination, she felt the need to apologize for her previous behavior.
One reason could be that Naruto has always been more attracted to those who understand his outcast past better. Sakura doesn't really have that kind of connection with him as she comes from a more normal background. So there's a lack of that fundamental understanding between them which hinders any romantic feelings.