His relationship with Kakashi would be severely affected. Kakashi has always taught Naruto about right and wrong, and Orochimaru is clearly on the wrong side in Kakashi's eyes. Naruto becoming a fan would make Kakashi feel like he has failed as a teacher. Also, with Sakura, she would be very concerned. She might think Naruto has been influenced by some dark power, and this could cause her to distance herself from Naruto, at least until she understands what's really going on.
It would likely strain his relationship with Sasuke. Sasuke has his own complex history with Orochimaru, and if Naruto becomes a fan, Sasuke would be very confused and probably angry. He might see Naruto as betraying their shared values. As for his friends in Konoha, they would also be worried and try to talk Naruto out of it, which could lead to some arguments and a rift in their friendships.
With his friends in Konoha, they would be worried and perhaps a bit afraid. They know Orochimaru's reputation as a villain. Naruto's friends like Shikamaru might start to keep a closer eye on him, which Naruto could resent. He would feel like they don't trust him anymore, and this could strain their friendships.
Well, his friends would likely be very confused and hurt. They know Naruto as a determined and kind - hearted person. If he's brainwashed, they might initially try to reach out to him, thinking it's just a temporary state. But as time goes on, they could become distrustful if he starts to act against them. Sasuke, for example, might be even more conflicted, seeing Naruto in such a different state. And Sakura would be heartbroken, as Naruto has always been a source of hope and friendship for her.
They could be related as adversaries with a strange connection. In fanfiction, Orochimaru might be after Naruto not just for the Nine - Tails, but also because Naruto has something that Orochimaru lost long ago. This creates a complex dynamic where they are constantly at odds, but there is also a deeper underlying connection.
Well, Orochimaru's immortality would mean that his influence would be long - lasting. He could continue to conduct his unethical experiments over a very long period. This might lead to the creation of new and dangerous ninja techniques or even new forms of life. In the long run, it could change the way ninja are trained and how the ninja world views power and knowledge. For example, some might start to see immortality as the ultimate form of power and strive for it at all costs. Naruto and his friends would have to constantly be on guard against Orochimaru's schemes.
When Naruto becomes Hinata, his relationship with Naruto's friends would be complex. He'd be in a female body and have to navigate through the different expectations society has for Hinata. His relationship with Kiba and Shino, Hinata's former teammates, would become more personal as he now shares Hinata's memories and feelings. And his relationship with Naruto's old crush, Sakura, would be a bit awkward as he tries to act like Hinata.
In a fanfiction where Naruto becomes an Orochimaru fan, perhaps Orochimaru has a change of heart and starts to use his knowledge for the good of the village. Naruto witnesses this new side of Orochimaru and is inspired. He begins to study Orochimaru's techniques more closely, believing that he can also use them for good. However, others in the village are skeptical and Naruto has to fight to prove that Orochimaru can be a positive influence.
His friends might respect him more for having a useful new skill.
Well, it would be a huge blow to his friendships. Naruto's friends are drawn to his big heart and strong emotions. An emotionless Naruto would not respond in the same warm way. He might not share in their joys or sorrows. Sakura, for instance, would miss his determination and the way he used to encourage her. His friends would have to work hard to reach out to him, but they may also start to drift apart because the emotional connection is no longer there.
In the Naruto fanfiction world, this could also inspire other authors to create more gender - bent or alternate - universe versions of characters. If fem Orochimaru's obsession with Naruto is well - received, it might encourage more creativity in terms of character development and plot creation. For instance, there could be fanfictions exploring the romantic or platonic implications of this obsession, which would be a departure from the more traditional Naruto fanfiction themes.
If Naruto was raised by Orochimaru in fanfiction, his relationships would be turned upside down. His friendships from the Leaf Village would be in jeopardy. Since Orochimaru is not one to value the kind of loyalty and friendship that Naruto's friends in the Leaf do, Naruto would have a hard time understanding and maintaining those relationships. He might even be hostile towards them, seeing them as obstacles in his pursuit of power. His relationship with the Hokage would also be a mess. Instead of looking up to the Hokage as a role model, he would probably view the position as something to be conquered or undermined, following Orochimaru's ideology of power - seeking.