One possible reason could be that he has some unresolved issues from his past, like the absence of his parents during his childhood which made him feel a sense of detachment. Maybe he is so focused on achieving his ninja goals that he unconsciously starts to ignore his family. Another reason might be some sort of miscommunication within the family. For example, if there are secrets that the family has been keeping from him, he might feel betrayed and thus choose to ignore them.
In some fanfics, Naruto may ignore Sakura because he has his own emotional traumas to deal with. He might find Sakura's presence a reminder of things he wants to forget or move past, so he chooses to keep his distance. For example, if he has faced a lot of rejection from her in the past, he could decide to just cut her out of his life.
Maybe he got some kind of curse. In the Naruto universe, there are all sorts of dark magic and curses. If he was cursed, it could make him withdrawn and cause him to ignore everyone.
It could also be due to some family curse or prophecy. In the Naruto universe, there are often strange powers and curses. Maybe there was a prophecy that said Naruto's family had to keep their distance from him to protect him from some greater evil. So, they chose to neglect him in order to keep him safe, even if it was a difficult choice.
One possible reason could be jealousy. Maybe Naruto has some special abilities or a prophecy surrounding him that makes his family members, who might be less favored, jealous. For example, if there's a prophecy that Naruto will be the most powerful ninja in the village, his siblings or parents might envy that future for him and start to hate him out of their own insecurities.
One possible reason could be that Kakashi is preoccupied with other important matters in the village. Maybe he has some top - secret missions or tasks assigned by the Hokage that demand his full attention, leaving him with little time to focus on Naruto.
Maybe there are secrets in the family. For example, his parents might be involved in some dangerous and secretive missions that require them to keep their distance from Naruto to protect him, but Naruto misinterprets it as neglect.
One possible reason could be jealousy. If Naruto has the rare Mokuton ability, his family might be jealous of his potential power and neglect him out of spite.
One possible reason could be a long - held misunderstanding. Maybe Naruto discovers some family secrets that he misinterprets as betrayal or neglect. For example, if he finds out that his family had made some sort of pact that he disagrees with, it could lead to his rejection.
Perhaps in the fanfiction, Naruto is exposed to a new philosophy or way of thinking that promotes forgiveness. He might meet a wise character who teaches him about the power of forgiving one's family. Also, if Naruto experiences a similar situation where he has to make a tough choice that might be misjudged by others, he could then understand his family better and forgive them. It could also be that Naruto finds out his family had no other option in the situations they were in, and this realization leads to his forgiveness.
A possible reason could be jealousy. If Naruto had a sibling who was always favored by their parents, he might grow to hate his family. He would feel like he was always in the shadow of his sibling and that his family didn't care about him as much.