Arya Stark is another potential main protagonist. Her skills as an assassin could be translated into a modern special forces operative. She could be sent on covert missions to take out key targets in rival houses or enemy military installations. Her ability to change her identity and blend in would be very useful in a world of modern espionage and military intrigue.
Daenerys would be a great main character. She could be a strong - willed CEO of a start - up aiming to disrupt the traditional corporate world, just as she aimed to change the power dynamics in Westeros. Jon Snow could also be a main character, perhaps as a journalist uncovering the dark secrets of the powerful families, similar to his discovery of the White Walkers' threat in the show.
One main character could be a genetically - enhanced human who has special abilities, like Arya Stark's skills in the original. She could be on a mission to avenge her family who were killed by a powerful space - faring clan. There could also be a powerful warlord from a distant star system, a bit like Ramsay Bolton, feared for his cruelty and thirst for power. The interactions between these diverse characters would drive the story forward in this space - based Game of Thrones fanfiction.
Arya Stark could be a main character. She could use her skills as a Faceless Man to infiltrate the enemy's camp before a big battle and gather intelligence. Her ability to change her appearance would give her an edge in spying and sabotage operations during the battle.
It could be Arya Stark as the bodyguard. Given her skills in combat and disguise, she would make a great protector. She could be protecting someone like Bran Stark as he continues to develop his powers and is a target because of his abilities.
The children of the original characters would be likely main characters. For example, Jon Snow's (if he has any) descendants. They could inherit his sense of honor and face new challenges in the post - war Westeros.
You could have a main character who is a commoner. Maybe a peasant girl who witnesses the fall of a great house and has to navigate the chaos that follows. She could get involved with the various factions vying for power, and through her eyes, we see the events of the prequel unfold. This would give a different perspective compared to the noble - centered stories we often see in the 'Game of Thrones' universe.
Gendry could also play a major role. As a skilled blacksmith and a bastard like Jon, he has the strength and the will to fight for change. He could use his skills to arm the revolutionaries and his knowledge of the common people's plight to inspire them to rise up against the unjust noble rule.
A Skagosian outcast. He could have been banished from his tribe for some reason, like not following their brutal traditions. This character would be interesting as he would be an outsider even in his own land at first, and his journey to either regain his place or find a new one could be full of adventure and self - discovery.
Bran Stark could also be the main character. His new powers as the Three - Eyed Raven give him a whole new perspective. He could be the one to guide Westeros into a new era. He could use his knowledge of the past and his ability to see things that others can't to make decisions that would shape the future of the Seven Kingdoms.
Melisandre could be a main character if you consider her as a kind of warlock. She has her strange powers, like seeing the future in the flames. You could write a fanfiction exploring her past, how she became a red priestess and gained her powers, and her further adventures in Westeros, perhaps with her using her powers in different ways than in the original series.