With his Slytherin peers, Draco's relationship would shift. He might encourage them to be more inclusive and less focused on pure - blood supremacy. This could make him an outcast among some of the more traditional Slytherins, but also gain him new allies who are open to change.
Another idea is that Draco travels back to the time of the founders of Hogwarts. He could interact with them and gain a new perspective on magic and the wizarding world. Maybe he would learn some ancient spells that were lost over time and use this knowledge to his advantage when he returns to his own time.
Well, for Naruto and Sasuke, their relationship might become even stronger earlier. In the past, they could train together more and understand each other's pain from the start. Sakura might be more assertive in her relationship with Sasuke, as she has the knowledge of what will happen in the future. She could try to prevent Sasuke from going down a dark path right from the beginning. And among the other members of Konoha 12, they might form closer bonds as they rely on each other more in this strange new situation of being in the past.
When they go back in time, they may encounter situations where they have to protect each other. This could be a big turning point in their relationship. Let's say they go back to a time when there were dark wizards targeting their families. They would have to put aside their differences and fight side by side. This could lead to a complete transformation of their relationship. Draco might realize that Harry is not his enemy and Harry could see that Draco is capable of loyalty and self - sacrifice. It would be a very different dynamic from their relationship in the original timeline.
Well, if Draco goes back in time, he might become more humble. Seeing the past and the mistakes his family has made or is about to make could make him less arrogant. He would realize that his pure - blood status doesn't give him the right to look down on others.
His relationship with his father, Ned Stark, would be different. He could finally have a real father - son relationship instead of the hidden one. He might be able to learn from Ned and become an even better leader in the North.
His relationship with Katara would be very different. He might be able to approach her in a more confident way, knowing what they've been through in the future. He could also avoid some of the misunderstandings that happened between them in the original timeline.
His relationship with Kakashi would also change. Naruto could use his Rinnegan - enhanced knowledge to help Kakashi deal with his past traumas earlier. He might also show Kakashi new jutsu or ways of combat that he learned in the future. This would make Kakashi see Naruto in a whole new light and their bond could become more of a teacher - student relationship in reverse.
In terms of her relationships with other Slytherins, the boys in the house might either be overly protective or try to take advantage of her. Some of the Slytherin girls might see her as a threat, especially if she's getting more attention from the boys or from the teachers. But there could also be a group of Slytherin girls who form a strong clique with her. And her relationship with Dumbledore could be one where he tries to encourage her to break free from the more traditional and sometimes dark Slytherin values, seeing her as a potential force for good in the house.
Regarding his relationships with his friends and comrades, like Samwell Tarly, things would be altered. He might not meet Sam in the same way as before. And his relationship with Daenerys Targaryen could be completely different. Instead of meeting her during the events of the original story, he could meet her when she was much younger, and this could lead to a very different kind of relationship, maybe one that's more of a mentorship or a completely different romantic connection.
Link's relationship with his own past self could be a really interesting aspect. If he meets his younger self, there could be a sense of mentoring or even confusion. His younger self might not understand what's going on at first. And when it comes to friends like the Koroks, if he goes back to a time when the Korok Forest was in a different state, their interactions would be new and different. The overall web of relationships would be completely reshaped as he steps into a different time period in Hyrule's history.