One possible plotline could be that Naruto is somehow tricked into leaving with Kisami and Itachi. Maybe they convince him that there is a greater threat that only they can help him face. Along the way, Naruto might start to learn more about their motives and the secrets of their pasts. He could also be in a position where he has to use his own skills and values to influence them.
In this fanfiction, it could be that Naruto is forced to leave with Kisami and Itachi due to a political situation in the ninja world. The three of them then become fugitives. As they run, they form an unlikely bond. Naruto might discover that Kisami and Itachi have some redeeming qualities despite their previous actions. They could end up working together to expose a conspiracy within the ninja villages.
Naruto's character could develop in terms of his understanding of different moral compasses. Kisami and Itachi have their own set of values which are very different from Naruto's. By being with them, Naruto might question some of his own beliefs and grow from that self - reflection. Kisami might develop a sense of loyalty towards Naruto, which is new for him as he has always been more self - serving. Itachi could find in Naruto a new reason to fight for a better future for the ninja world, leading to a change in his usually stoic and secretive demeanor.
One possible plotline could be the challenges they face in a world that might not be accepting of their relationship. With Itachi being pregnant, they have to deal with secrecy and the potential danger that could come to their unborn child from various forces in the Naruto universe.
One possible plotline could be that Naruto is forced into a situation where he has to kill Itachi to protect the Hidden Leaf. Maybe Itachi is being controlled by some dark force and Naruto, with great reluctance, has to end his life to save the village and his friends.
A plotline might involve the two of them in a world where gender roles are more fluid. Effeminate Naruto and fem Itachi could be part of a mission together, and during the process, they discover new aspects of each other's personalities. For example, Naruto's kind - heartedness and Itachi's hidden soft side. Their relationship could develop from mutual respect to something deeper as they face various challenges. And perhaps they have to deal with the reactions of their friends and the ninja community to their relationship, which adds more drama to the story.
One possible plotline is that Fem Naruto and Itachi are assigned to protect a valuable village asset. Along the way, they face numerous enemies and have to work together to overcome them. As they fight side by side, they start to respect each other's abilities more.
One possible plotline could be that Naruto leaves with Tsunade on a mission to find a rare herb that is said to have the power to heal any wound. Along the way, they face various enemies who also want the herb for their own malicious purposes. Naruto's skills and Tsunade's wisdom would be put to the test as they battle their way through.
One possible plotline could be that Naruto discovers some long - lost secret about his mother Kushina and decides to leave the village with her to explore this mystery further. Maybe they are on a quest to find some hidden power or knowledge that is related to Kushina's Uzumaki heritage.
One possible plotline could be that they got married to form an alliance between two powerful factions secretly. Another could be that they fell in love while on a secret mission together that no one else knew about. Maybe Itachi was on a mission to protect Naruto from afar and they developed feelings over time.
One plotline could be that Itachi, with his powerful abilities, tries to find a way to cure Zombie Naruto. He embarks on a journey to find rare herbs or seek out ancient jutsu that might reverse the zombification. Along the way, they face various enemies who either want to use Zombie Naruto for their own evil purposes or are simply in their path as they travel through different regions of the Naruto world.
One possible plotline could be that they become closer friends early on. Since they are the same age, they might train together more often. They could also share secrets that in the original story they wouldn't due to the age gap. For example, they might both have dreams about the future of the village that they can discuss on an equal level.