There could be fanfictions with that plot. It could be that in the fan - created world, Sakura has been really cruel to Naruto's feelings. She might have chosen someone else over him repeatedly and publicly humiliated him for his feelings, which could shatter Naruto's self - esteem and make him feel like there's no way out but to end his life.
One possible reason could be a sudden and extreme corruption of Naruto's character. Maybe he is influenced by some dark and powerful force that makes him turn against his friends. Another reason might be a misinterpretation of a prophecy or some kind of mind - control situation.
In such a fanfiction, one possible storyline could be that Sakura is under some dark magic or mind control which makes her turn against Naruto. Another could be a huge misunderstanding where she believes Naruto has done something unforgivable to her or their friends.
Another reason could be a very dark and alternative interpretation of the characters. Maybe the writer has a different view of Naruto's character arc and how he could be pushed to the extreme. And they see Sakura as a character that could be sacrificed in this extreme version of Naruto's story. But this is a very far - fetched view considering the original story's development.
If such a fanfiction exists, one possible reason could be a mind - control situation. Maybe an enemy uses some powerful genjutsu to make Naruto believe his sister is a threat, causing him to kill her accidentally. Another reason could be a misinformation plot where Naruto is tricked into thinking his sister has committed some unforgivable crime against the village.
Perhaps there is a situation where Sakura is trying to protect Naruto from a dangerous attack, but due to some unforeseen circumstances, like a misdirected healing jutsu turning into a harmful one, she ends up killing him. It could then lead to a story of guilt, revenge, and the search for a way to bring Naruto back.
One reason could be that Naruto has always been more attracted to those who understand his outcast past better. Sakura doesn't really have that kind of connection with him as she comes from a more normal background. So there's a lack of that fundamental understanding between them which hinders any romantic feelings.
In some fanfictions, it could be due to unrequited love. If Naruto has deep feelings for Sakura but she continuously rejects him in a cruel or thoughtless way, Naruto might feel angry enough to seek revenge. For example, she could publicly humiliate him for his feelings, which would hurt Naruto deeply and lead to thoughts of revenge. Another reason could be a misunderstanding. Suppose Sakura is misjudged by Naruto as having done something terrible when in fact she was innocent. But Naruto, in his ignorance, decides to take revenge. This can create a lot of drama and conflict in the fanfiction.
One reason could be jealousy. If in the fanfic, Sakura gets closer to someone else Naruto cares about, like Sasuke in a different way than he expected, it might make him hate her. For example, if Sakura teams up with Sasuke against Naruto's wishes in the fan - created plot.
There could be. Fanfiction allows for a wide range of interpretations and alternate storylines. But it's a really extreme and disturbing concept considering the bonds that Naruto, Sakura, and Sasuke share in the official story. It would be a very different take on the characters, and most fans who love the original story would probably find it hard to accept.
One possible reason could be a miscommunication that escalates out of control. Maybe Sasuke is on a path that Naruto believes is too dangerous for the world, and Naruto, in an attempt to stop him, accidentally kills him. For example, Sasuke might be about to use a powerful and uncontrollable jutsu that Naruto fears will destroy the Uchia compound and much more, so he acts in haste.