Sure. There are some sakura and frieza fanfictions. They often play with the contrast between Sakura's more earthly and human - like qualities and Frieza's otherworldly and often villainous nature. Some stories might have Sakura trying to reform Frieza, while others could be about them fighting against a common enemy.
One common theme is power struggle. Given Frieza's obsession with power and Sakura's own growth in power, their interactions often revolve around this. Another theme could be redemption, where Sakura tries to make Frieza see the good side of things.
Perhaps in a fanfiction, Frieza encounters a planet where the main female lead is pregnant. He initially plans to destroy the planet as usual, but something about the woman's condition and her determination to protect her unborn child makes him hesitate. This hesitation could lead to a series of events where Frieza's character undergoes some sort of transformation as he gets involved in the affairs related to the pregnant character.
One possible plot could be that Gohan discovers an injured alien creature that he decides to keep as a pet. However, Frieza somehow gets wind of this unique pet and wants to take it for his own evil purposes, like using its powers for his galactic domination plans. Gohan then has to protect his new pet from Frieza.
One possible plot could be that Yamcha, known for his tenacity, somehow ends up in a situation where he has to team up with Frieza. Maybe they are both forced to face a common enemy that is even more powerful than Frieza at his peak. This could lead to an interesting dynamic as Yamcha tries to get Frieza to work as a team, while Frieza is his usual self - conniving and power - hungry. Their interactions would be full of tension and mistrust at first, but over time, they might develop an odd sort of respect for each other.
The potential for new storylines is great. Since Frieza is an alien with a thirst for power in his original story, in the Fairy Tail fanfiction, he could be seeking new forms of magic or power sources. This could lead to him exploring different parts of the Fairy Tail world, encountering various magical creatures and ancient spells, which all make for really engaging reading.
One idea could be that Frieza somehow ends up in the wizarding world. Maybe he's initially interested in the powerful magic there to increase his own strength. He could try to take over Hogwarts, thinking it's a place full of valuable secrets. Another idea is that Harry Potter and his friends discover a way to travel to Frieza's universe and they have to use their magic to survive and find a way back home. Or perhaps Frieza is magically transformed into a Hogwarts student and has to deal with the rules and social life at the school while still having his evil tendencies.
One interesting plot could be Goku and Fem Frieza having to team up against a new, powerful enemy. Maybe this enemy is threatening both of their planets or has some power that neither can defeat alone. Another plot could be Fem Frieza falling in love with Goku and trying to change her evil ways to be with him, but struggling with her past and her reputation among the villains.
In frieza race crossover fanfiction, a cool idea is the Frieza race having to deal with moral concepts from other races. Since the Frieza race is often portrayed as more ruthless, they might struggle with ideas like compassion and justice. Also, their unique biological features could be used in interesting ways. For instance, their ability to survive in harsh conditions could give them an edge in certain crossovers, like in a post - apocalyptic world crossover.
One idea could be that Kuriza, as Frieza's son, tries to redeem his father's name. He could start by training hard to become stronger than Frieza ever was. In the fanfiction, he might encounter the Z - fighters and instead of fighting them, he asks for their help in changing the ways of the Frieza race. He wants to break the cycle of tyranny his father started.
A plot could involve a love triangle where Female Frieza has feelings for Goku, but Goku is oblivious and focused on his own goals. Meanwhile, another character is also interested in Goku. This could lead to a lot of comical and tense situations. Or perhaps Female Frieza challenges Goku to a series of contests not related to fighting, like cooking or dancing, to prove she can be better than him in other areas.