Another option could be a new student who is secretly a Hydra agent. He or she tries to divide the Avengers, turning them against each other. They spread rumors and create misunderstandings among the group, all while working towards some evil plan like stealing a powerful artifact hidden in the school.
Loki could be a great main antagonist. He could be the mischievous student who's always causing trouble for the Avengers. He might use his magic to play pranks on them or steal their homework to make them look bad in front of the teachers.
Perhaps it could be an alien student who is jealous of the Avengers' popularity. This alien has some powerful abilities and decides to use them to take over the high school. They start by taking control of the school's security systems and then move on to trying to defeat the Avengers one by one.
It could be a jealous classmate. Maybe someone who has a crush on Armin and sees Annie as a threat to their relationship. This person could try to spread rumors about Annie to make Armin stay away from her.
Perhaps a strict teacher who doesn't like Naruto's unorthodox ways and Anko's rebellious attitude. The teacher might try to split them up and prevent them from participating in school activities together. For example, if they want to enter a school competition as a team, the teacher could create obstacles.
Perhaps a jealous classmate who discovers Artemis's connection to the fairy world. This classmate wants to use that knowledge to gain power and popularity, so they start causing trouble for Artemis and his friends, trying to expose them to the wrong people or get in the way of their fairy - related investigations.
Perhaps Orochimaru from Naruto could be the main antagonist. He's always seeking more power, and in this fanfic, he might see the powers in 'The God of High School' as a means to achieve ultimate power. He could try to manipulate the events of the 'The God of High School' tournaments to his advantage, all while causing chaos in Naruto's world as well.
Gary could be a main antagonist. He might be jealous of Ash's popularity at school and constantly try to undermine him in Pokemon battles and in front of their classmates.
A new, original villain created just for this fanfic could be the main antagonist. This villain could be a powerful sorcerer who has been observing the Avengers from the shadows. When the OC is reborn, they sense a disruption in the magical balance of the world. Believing the OC to be a threat to their own plans of ruling the world through magic, they set out to eliminate the OC and in the process, come into conflict with the Avengers.
Thanos could still be a great antagonist even in a fanfic. He could come back with a new plan to obtain the Infinity Stones again. His powerful and menacing presence would create a high - stakes situation for Captain Marvel and the Avengers to face.
It could be a high - ranking military official who believes the Avengers are a threat and is determined to stop them at all costs. This person might see Bucky as a dangerous weapon and want to capture or eliminate him.
It could be the school principal. The girl wants to put on a more edgy and progressive play that challenges some of the school's traditional values. The principal, being more conservative, tries to stop her from doing so. He or she makes it difficult for her to get the necessary resources and permissions, becoming the main obstacle in her acting journey in high school.
Perhaps a former teacher who always had it in for Pete. At the reunion, this teacher could be there as a guest and start criticizing Pete's life choices or bring up old mistakes he made in school. The teacher might be jealous of Pete's new - found confidence or success and wants to put him down.