A new, original villain created just for this fanfic could be the main antagonist. This villain could be a powerful sorcerer who has been observing the Avengers from the shadows. When the OC is reborn, they sense a disruption in the magical balance of the world. Believing the OC to be a threat to their own plans of ruling the world through magic, they set out to eliminate the OC and in the process, come into conflict with the Avengers.
It could be a powerful Arrancar. In the Bleach universe, Arrancars are often antagonists. A particularly strong and cunning one might see the oc as a threat to their plans. Maybe the oc's presence disrupts the Arrancar's scheme to take over a certain part of the Soul Society or gain more power.
A powerful dark mage who was once a member of Fairy Tail but was banished for using forbidden magic. This mage now wants revenge on the guild and sees the reborn OC as a threat to his plans. He has the ability to control shadows and can create illusions to deceive the members of Fairy Tail.
It could be a new character created specifically for the fanfiction. Maybe a powerful pirate who has a vendetta against the Straw Hat crew because of the oc's presence. Since the oc is reborn into this world, they might bring some sort of change that angers this new antagonist.
Maybe there is a new character created specifically for this fanfiction as the main antagonist. This new character could have a connection to the oc's past life or the reason for their rebirth. They might be trying to prevent the oc from fulfilling a certain destiny or unlocking their full potential.
Another possibility could be an original antagonist created specifically for the fanfiction. For example, a powerful sorcerer from a hidden dimension who sees the OC's rebirth as a disruption to the natural order of the MCU universe. This sorcerer could try to eliminate the OC and use their power for their own dark purposes. They might be able to manipulate magic in ways that even Doctor Strange hasn't seen before, making them a formidable foe.
Perhaps another reborn character could be the main antagonist. Say, an evil sorcerer from the past who was also reborn in the Inuyasha world at the same time as the OC. This sorcerer has his own agenda of ruling the world and sees the OC as a threat to his plans, especially if the OC is getting in the way of his attempts to gather the Shikon Jewel fragments.
Loki could be a great main antagonist. He could be the mischievous student who's always causing trouble for the Avengers. He might use his magic to play pranks on them or steal their homework to make them look bad in front of the teachers.
Thanos could still be a great antagonist even in a fanfic. He could come back with a new plan to obtain the Infinity Stones again. His powerful and menacing presence would create a high - stakes situation for Captain Marvel and the Avengers to face.
An organization of rogue scientists who want to experiment on Pokemon could be the main antagonist. They might be trying to create super - powerful mutant Pokemon or find a way to control all Pokemon. If you're reborn as a Pokemon, they might capture you for their experiments. This could lead to a story where you have to escape from their labs and expose their evil plans to the rest of the Pokemon world.
Well, the plot could be that the OC (Original Character) is reborn into the Avengers' world with some special powers. Maybe they start off as an unknown, but gradually gain the attention of the Avengers through their unique abilities, like being able to control an element that no one else can. Then they get involved in the Avengers' battles, helping them in unexpected ways.