Konoha would initially be in shock. Naruto is a hero to many in the village, and his sudden departure with Itachi, who was once considered a traitor, would cause a lot of unrest. The villagers might start to question the leadership of the village, wondering why Naruto left and if there was something they could have done to prevent it.
The security of Konoha could be at risk. Naruto was one of the main protectors of the village, and with him gone, the village would be more vulnerable to attacks from other ninja villages or rogue shinobi. However, this could also be a chance for other young shinobi in Konoha to step up and prove their worth, leading to a new generation of strong protectors.
It could lead to political unrest in Konoha. There might be those who blame the village leadership for Naruto's departure. This could lead to power struggles as different factions try to take control and change the way the village is run. Some might demand more transparency and better treatment of their shinobi to prevent such a thing from happening again.
It could create a sense of unease and fear. Naruto is a very powerful ninja, and if he turns dark and leaves, the villagers would be worried about him coming back as an enemy. It might also lead to a decrease in morale among the ninjas who once considered Naruto a friend or ally.
On a more positive note, it could inspire some young ninja to step up. They would see Naruto's departure as a challenge to prove themselves and fill the gap he left. His leaving could also make Konoha re - evaluate its relationship with its ninja and how to keep them satisfied and in the village.
Konoha's power structure could be affected. Naruto is one of the strongest shinobi in the village. Without him, the village might be more vulnerable to attacks from other villages or threats. They would need to quickly find ways to fill the gap in their defenses.
Well, it would be a big loss for Konoha. Naruto is a powerful ninja, and his absence would mean one less strong fighter to defend the village. Ino, too, has her unique skills in mind - related jutsu and communication. Their departure might also lower the morale of other ninja, especially those who were friends with them or looked up to them.
Sakura would be heartbroken. She has deep feelings for Naruto, and his sudden departure would make her feel abandoned. She might initially be angry at him for leaving without saying goodbye but would soon worry about his safety.
His friends would be worried. Sakura might be very concerned about his safety and feel sad that he left. She may also feel guilty if she thinks she could have done something to prevent his departure.
His relationships with his friends like Sasuke and Kakashi would also be affected. Sasuke might understand Naruto's decision on some level, having also left the village before. Kakashi, on the other hand, would be worried about Naruto. He might try to find him and bring him back. This could create some tension between Naruto and Kakashi as Naruto tries to assert his independence.
One possible scenario is that Naruto starts to learn new and unique jutsus from Itachi. Itachi is highly skilled, and he could pass on some of his knowledge about the Sharingan and powerful genjutsu. Naruto, with his determination and Itachi's guidance, might become even stronger, and they could form a plan to deal with the threats to Konoha that they both know exist.
Kakashi would be worried. He has always been a mentor to Naruto. His departure would make Kakashi feel like he failed in some way. He would probably try to find Naruto to bring him back or at least make sure he's okay. The rest of the Konoha 11 would also be affected. They would miss Naruto's presence and some might even question the village's decision (if there was one) that led to Naruto leaving.