Sakura would be heartbroken. She has deep feelings for Naruto, and his sudden departure would make her feel abandoned. She might initially be angry at him for leaving without saying goodbye but would soon worry about his safety.
His friends would be worried. Sakura might be very concerned about his safety and feel sad that he left. She may also feel guilty if she thinks she could have done something to prevent his departure.
It could lead to political unrest in Konoha. There might be those who blame the village leadership for Naruto's departure. This could lead to power struggles as different factions try to take control and change the way the village is run. Some might demand more transparency and better treatment of their shinobi to prevent such a thing from happening again.
It could create a sense of unease and fear. Naruto is a very powerful ninja, and if he turns dark and leaves, the villagers would be worried about him coming back as an enemy. It might also lead to a decrease in morale among the ninjas who once considered Naruto a friend or ally.
Some of his friends could be inspired. They might see Naruto's departure as a noble act, especially if he's leaving to protect his family. Naruto has always been a source of inspiration, and this could lead them to re - evaluate their own relationships and responsibilities. For instance, Sakura might be motivated to be stronger to support Naruto's family in his absence.
Konoha's power structure could be affected. Naruto is one of the strongest shinobi in the village. Without him, the village might be more vulnerable to attacks from other villages or threats. They would need to quickly find ways to fill the gap in their defenses.
Kakashi would be worried. He has always been a mentor to Naruto. His departure would make Kakashi feel like he failed in some way. He would probably try to find Naruto to bring him back or at least make sure he's okay. The rest of the Konoha 11 would also be affected. They would miss Naruto's presence and some might even question the village's decision (if there was one) that led to Naruto leaving.
Some friends might feel betrayed. If they are very clan - oriented, they could see Naruto's leaving as a sign that he doesn't value the clan and by extension, their friendship. However, his true friends like Sasuke or Sakura might understand his reasons. Sasuke, who has his own issues with his clan, might be more empathetic. Sakura, who has seen Naruto's determination, could support his decision in the long run.
Shikamaru and the others from the Rookie 9 would be shocked. They have always counted on Naruto to be there in Konoha. They would probably feel a sense of loss and also a bit of guilt, wondering if they could have done something to prevent Naruto from getting so tired of the village. They might try to find ways to get him back, while also respecting his decision if he is determined to leave.
His departure would definitely put a strain on his relationships. His close friends like Sasuke, if he is back in Konoha at that time, would have mixed feelings. They might worry about Naruto but also be a bit angry that he left without consulting them. Naruto's younger friends like Boruto would be confused and miss him a great deal, and this could lead to some distance in their relationships.
It can create a big shift in the power dynamics. If Naruto was a key member in the Anbu, his departure might leave a gap that other characters have to fill. This could lead to new characters emerging or existing characters having to step up and take on more responsibilities.