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When Chris learned that Ivan lost his daughter, he felt a strong grief.
But he wasn't able to go help him or something, as he was in the middle of a mission.
But when she died was… the turning point for Ivan.
He changed.
It could be said that the old Ivan died with his daughter and his wife.
And what emerged afterwards was a man born from suffering and sorrow, an insane persona that wasn't really Ivan as Chris knew him.
After the death of his daughter, Ivan used his studies and investigations as a way to cope.
He put his mind into only that and nothing else.
Stealing secret information from the Organization and more, he did it all for his goals.
The goals to make a virus with the power to make humans invincible.
Virus had a particularly interesting ability, the way they caused diseases was by parasitizing a cell and infecting them, changing their DNA, and duplicating themselves within it.