One morning Seth wakes up to find his family dead, he passes out and wakes in a mysterious place. After a while he creates some friends whom he learns to trust eventually. What will Seth do?

After having been caught masturbating by his entire class, Tai was left with no choice but to try his luck at suicide, hoping for something fruitful to result of that. How will the new life of the nineteen-year-old teenager differ from his former one?

200 years ago man created the greatest AI known but this Machine eventually grew a mind of its own and evetually it's own body, it rose up with others like it against the human race this battle went on for about 20 years and nature and most resources were dieing off cause of the continuing battles but the final battle it released a large blast but is wasn't a bomb it was something else entirely, the machines had something hidden down their main base, something that wasn't human or machine something not of this earth, the blast brought back nature it changed it along with the humans and Machines closes to the blast.....both of them went a evolution of some sorts and because of this both sides where able to form a peace ending the war



Lia Giles became a border guard and mechanic for the power lines on the in between of the main city and the unearthly forests, no longer being able to stand living in the high technology world where humans are treated like second class citizens. On one of her patrols she discovers something or more like someone that no one has ever seen before.

The morning sun was blinding, the heat monstrously beating down. What didn't help was that today was the day they would travel to the castle, but her only issue that caused paranoia to flutter... was that Aloysia hadn't been told anything.
She yawned sheepishly, stretching her back that punished her for sleeping awkwardly. Nerves were tickling her, a constant annoyance; one that she wished would leave her wretched existence.
She hated the silence, eyeing Belinda with an air of caution. "Viper, I don't trust you, so tell me what in the name of Caswor is going to happen? You haven't given me anything!" she huffed, pulling her shoulders back and feeling the foreign material over her body.
Viper glazed back and laughed, eyes squinting from the light while her arms hung over the balcony close to the top floor. She smiled innocently while admiring the view, "I do not expect you to trust me. In fact..." she propelled herself from leaning casually, one hand resting on the banister, "if you did, you'd be a bigger fool than I thought"
"Charming" She drawled, raising a cocky eyebrow. The clothing the assassin wore was different... it was that of a guard... Viper's guards. However, Aloyisa had refused to lay her scars on her shoulders, being adamant that the stark, dark scar on her chest was covered.
So as her hands trickled down the wide necklace creating the shape of a crescent, she took a sigh of comfort.  
Feeling less exposed, her skin sizzled at the warmth; she had noticed she was less lethargic and wasn't as clammy thanks to the less layers. Some benefits perhaps?
It held no hood however, so her eyes were as bright as the early morning sun; wide awake and for all to see. She pushed with a grunt, still fiddling with her clothing, "I do not understand how you can orchestrate a plan without telling the individuals involved?"
Viper huffed, "Says you, you practically do that all the time!"
"Touché. But not the point"
"Oh?" Belinda proclaimed, tilting her head, "What is your point then?"
Aloysia sashayed closer, gaining a feel for the loose material; her blades attached to her hips, her voice turned serious, "My point Viper- is that when someone's life besides mine is on the line, I care to know the details"
Belinda grinned, her golden eyes flaring with a cheeky expression. "So... in other words, you care for the Prince?"
"Don't get cocky with me" she flashed, "I care for this world that I just so happen to live in, and if it wants to be taken over by a madman while I hold the key in the form of a boy, then yes, I do care"
Belinda smiled, "Touché"
Lifting her nose at the assassin, Aloysia asked slightly quieter, "And how will you deal with hiding my eyes, this outfit doesn't exactly win the best award for concealment you know"
"Calm down Shadow, I'm aware"
The sound of the morning marketeers setting up shop was refreshing, flying with the wind that swept through her darkened hair.
Yes, her hair with the help of an un-relenting assassin was coloured a dark shade of brown, on the verge of black. It felt odd, but suited her nevertheless.  
"I'll deal with it the same way we dealt with your hair"
Aloysia visibly shivered, retracting with a scowl on her lips, "You are not suggesting to 'dye' my eyes? That would make me blind!"
Belinda shrugged, clicking her tongue, "If it comes down to it..."
Aloysia stepped back, her face in utter disgust; Viper watched satisfied, grinning to herself, "I'm joking Shadow, I'm not an imbecile, I have something just for that" she turned, "Without, making you blind"
She did not trust the assassin as she sauntered off inside, leaving Aloysia alone with nothing but her thoughts. Everything was risky, so dam risky it threw her off.
Usually, and as she had explained to Viper... if it was just her life on the line, just her life hanging over the danger zone... she wouldn't hesitate, because truthfully... she didn't care what happened to her, but its consequences... that she kept in mind. It was why she decided to stay alive, to find a way to fix the world. In a sense, she thought herself as childish, and the sweet relief of death un-deserving.
In a heartbeat, she would be the deciding factor, the sacrifice if it meant others could survive, because genuinely, she meant nothing to this twisted world. She would leave it behind if it asked her... without a doubt; believing that people who had lived a certain life and left a trail of blood as they walked, did not deserve redemption; did not deserve to smile, not when the things they had done tormented others; for the better, or for the worse.
Her outlook on life was grim, which is why when it was Liam's soul hanging in the balance, she would do everything in her power to insure his safety. But not only that; his happiness also.
She sighed heavily, wondering where the assassin could have gone off too when a certain noise caught her attention; the patter of footsteps made gingerly by a prince she knew. Peering up, she folded her arms, waiting patiently for his foot to hit the last stair, but when it did, she froze.
His attire caught her off guard, her blessed sight detailing that of a traditional man in the west, his groomed hair fluttering at a longer length... It suited him so well and brought out components un-beknowing to her that she forced her eyes to peel away, coughing lightly.
She had never seen him without a shirt on.  
Liam on the other hand held the same reaction, but to her. He almost didn't recognise her as he took that last step; the vibrant eyes that stared in awe being the only familiar aspect. Her scars still littered her body but they somehow complimented her attire with an edge of roughness that demanded respect... and her hair...
His lips turned smug as he admired her darkened hair cascade to her shoulders. In the natural light she was highlighted perfectly.
There was only one way to describe her. Breath-taking.
She coughed, snapping out of his attention, but when she swivelled on her heels to face him, he held back breath.
Even when draped with a light fabric, her toned stomach and waist was on full display; her arms matching in definition. It was normal for an assassin as masterful as her to look the way she did, but but by the assessment of her body structure, she was much stronger than he realised, almost scared for being crushed under her strength.  
Her clavicle shone prominently, her lips a tight seal as she coughed for a final time, noticing the staring and growing hot and bothered.    
"Liam" she called, bringing his eyes back to hers. Her smile turned cheeky as she sniggered, "Looks good on you, you should not wear a shirt more often"
Its true, even without high definition his chest remained something to gaze at; he had maintained his fitness over the last few weeks travelling, albeit not as well as her.
He laughed, "Thanks, the clothing suits you too"
She rolled her eyes, "Of course it does, I look good in anything"
She was dam right. He was awe struck.
Fumbling for words, he was saved perfectly by a lonesome Viper trotting in behind him as if she committed a murder and happily pinned it on another. Viper actually however, returned from a tiny incursion with a hand sized box in her fingertips.
Following it with his eyes out of curiosity once she brushed past him, Viper smiled, handing the box to a befuddled Aloysia.
"This is for you, treat it with care because it costs more than you're worth"
Aloysia chuckled, taking the box from her with caution, "Not much then"
"Don't act coy, it is for your eyes dumbass" she clicked.
Aloysia carefully opened the box, head dipping to peer into its depth expecting to find something miraculous. Instead, a vial half the size of her finger greeted her with a label in Relis.  
She gave a worrying glance to the assassin, "And what do I do with this?" she asked.  
Belinda had a hand placed to her hip, taking the vial from the cushioned box. She held it in-between two fingertips, holding it up against the sun, "Inside there is an experimental liquid, when a drop is placed in the eye, the pigments react to form a different colour"
Hearing all this, Liam wondered closer, amazed at the technology of the west, far advanced than the rest. Belinda glanced over her shoulder, her piercing reflecting the sun as she whispered, "This is not the only revelation we have made in the past years, no kingdom knows about it"
This gravely worried Liam's mind, his eyebrows needlessly furrowing, "I thought the contract signed between all kingdoms stated any discoveries had to be shared, or was that a bunch of lies?"
Belinda went wide-eyed, blinking slowly. "I didn't know you were that knowledgeable Your Highness, but do not fret, for this is still in an experimental stage"
"Experimental?!" Aloysia hissed, causing the assassin to withdraw from blades distance.
Viper shrugged. "Its safe, even if it is experimental"
She wanted to swear, swiping the vial and growling lowly as she steadied herself. Both Liam and Belinda waited patiently, watching her with intent as the assassin writhed in the attention.
Swallowing all fear, she threw caution to the wind and administered the drops into each eye. The liquid was a pale blue, slowly burning its way into her iris as she held her head to the sun.
Blinking furiously, she shook her head and squinted.
Liam held a hand to his mouth as he stepped forward and examined her, but what he saw altered his perspective forever; a smug expression plastered on Viper behind him having seen it many times before. It never failed to impress.
The image of a crimson red swirling around a pale blue colour was astounding; the colour bleeding into the other as her eye changed from the familiar orbs of pain to a canvased sky.  
Belinda waited in the hazy silence, tapping her foot as she gazed over the balconies edge. Deciding she was far more important than some colour change, she called from behind, "It wears of after 6 hours, so keep it with you"
Ignored.
Laughing at her third wheel situation, she couldn't help but smirk, "If you're done gazing into each others eyes, our transport is here. I'll explain what is going to happen on the way"


The man's face was inches from him as he spat, "Even death is too good for filth"

The pure hatred that he spoke with was un-wavering, strengthening his grip on the man now squirming in his hold. 

"I- I- didn't-" he could hardly choke out a word, his hands trying desperately to remove the ones dragging him further up the wall.

He was like a restless animal caught in the claws of defeat.

"Save your breath" he breathed down the man's face, eyes condescending.

She'd seen enough.

~

Attention to detail is key, worlds are only separated by the imagination as they are brought together by the same force.

Aloysia, an assassin, being the one who has to drive through life with a secret. One that keeps growing and attracts attention once it cannot be kept to the shadows.

What is it? Why is it so dangerous? 

Only she knows, and only those on the opposing end of this secret could tell you... if they weren’t already dead.

What lengths would she travel to save her world, her friends, herself...

While that secret gave her something to be feared by, it was thought to slowly be killing her- a double edged blade.

Will time remain on their side? Will the blurry future become clear? Or will it remain shrouded in the fog of pain that houses a lingering, eerie shadow from within?

System waking... Box opened. System drone lift. System protocol recounted. 

Good morning... Is there tea left? 

No... plant 9 through 60 expired. Weather and moisture system of internal plant cells expired for the winter. System recommends pouring all drinks and foods into box directly for higher yield of energy productivity. 

Why? 

System is able to release back out of restriction information protocol. Host is stable and able to take information better. System beleive that information would have had negative impact 9 weeks ago. Host shows stable mental health consist and ability to follow survival needs without system assistance. 

Oh, no secrets. I like the sound of that. So if I sit now and listen. You will tell me more about what exactly you do know of the time you called host definition of death. 

System adjustment to information according by response of host. Logic processing and network information organized. Predictions run through... satisfied for response counter actions. 

Must be serious if you considering on restaining me after I have listened. Is it that bad? 

Yes. System organised with logical protocol ready. What does Kate wish to know about most or does she wish to know the important facts first? 

I think the most important facts must be told to me. Say it as it is... don't make it out better then it is. 

Host is not longer human by biological or atomic structures. All organs including the brain is located in box. Hosts beleif of self is assuming drone control. Host is by definition dead. However... csccc disease configuration and the other diseases are cause of brain still active in spite of detachment to other vital organs. System relies on host for energy and logical choose making. Without host means total system deconstruction. 

Thats a lot to take in... I am glad to be sitting down. Wait... let me take this in for a while. Because it so confusing to me. Everything I feel now and assumed is hard to consider as sense. 

System has one more very vital information. 

Go on... I am already really shocked. I can't really have a heart attack without a heart. 

The 64 percent of unknown disease is actually a successful experimental DNA cell configuration created by city dome scientists. A success population alteration to allow nanotechnology configuration in demihuman bodies. Unsuccessful as of yet to dna alter genetic data of demi humans into pure humans. Data of any further testing was cut from leave of the city networking. Eight of the frozen pre-war subjects of 20 had violent or destructive actions upon hearing this information. 

I can't blame them. Its rather funked up. 

System alter language use. 

This is my mind, I think as I like. Like it or not, I am still here... in sense. Until this voice of my mind is broken beyond repair or that my brain rots. I am still here. If something about my inner mind voice or you detect inactivity thinking. You can assume I am gone. You have to promise me   something very serious. 

System is accepting to listen to promise. 

I promised to protect living beings. I can't really recall that well of whom I said it to. But it is very important to me to never hurt or cause harm to another living being. That I must help anyone that needs saving. If I am capable to do it and I know it without fail that I can. Then I am going to save them. It can be a animal, a creature, a human and even a ai like you. If I can protect and save someone else... I am doing the right thing. Can you keep this promise? If I am gone, my mind that is, you will protect like I do. 

System has recorded strong emotional promise and has added additional background logical choose programs. System has configured final testament wishes and has logical protocol choose making for any accidental death causes in the the meantime. System settings will be adjusted accordingly. 

I guess that is a yes? You will protect life.

System will protect life but has many questions of definitions. 

I do too... its not simple anymore. Life is always so complicated. 

System knows that is human saying but doesn't help definition. 

You will learn. Your still so young... for a machine. 

Detected positive impact. System processing how it is joke. 

Well it wasn't a joke. But I guess things like this make more sense for you the more connect we become. 

System wishes to have rating of how you felt about the secert kept from you. 

Ugh... let me think on that. I am still getting over it. The shock of what you meant. 

System said it straight forward as requested. 

Its just a complicated information that takes time to accept. Ugh... it being processed and reconfigured as logic?

System understands host. Its is 10am. 

Yes... I have to make breakfast... of just throw it in the box... I guess. 

System is glad of host understanding.

This was originally a delicious box of old scrap personal diaries that follow a stranger. Although as the further into the books I became, I had the urge in seeking the rest of it. 

Given this was a time of machines. I had my luck in finding the right souls. A sort of system has scanned, registered and submitted all data into some hidden storage database. 

Apparently 'any alterations were consult with administrator. All data from corresponding subjects was included among the scanned records, sometimes blended into the narrative. Makes for easier storage and reading flow.' I wasn't the only one who fell into the reading then. 

 ___________________________________
Real Author (Kittah): 

This story is not a typical female lead novel, not a lot of romance but coping in a post apocalypse. Which I don't get why female lead novels have to have a element of romance. It starts out as a diary should but further on, things change. The world around was the one we know of now but this story is later set in the unknown future. At times it can feel like I am trying to write a horror novel, but that's not what it is. This really is just a bumpy journey of a female character. 

I must rewrite my disclaimer which is the author note of chapter one. This seems like it relevant to today with the global pandemic. However the inspiration is my personal experience during the swine flu outbreak in the UK around 2012 or 2013. The majority of this story is prewritten but I have been changing it since putting it online. 

And, yes story does spill over into the author notes. You will understand in the later chapters. It's a writer's choose.

May the odds be in your favor.

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￼

Experimental Rat

Laboratory rats treated for up to 4 days with either selective COX2 inhibitors (rofecoxib, celecoxib) or nonselective COX inhibitors (diclofenac, flurbiprofen) showed a progressive reduction in sodium and potassium excretion (Harirforoosh and Jamali 2005).

From: Comprehensive Toxicology, 2010

Related terms:

Protein

Inflammation

Experimental Animal

Experimental Mouse

Toxicity

Rat Model

Mammal

Rodent

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Occupational Health and Safety

Sanford H. Feldman, David N. Easton, in The Laboratory Rat (Second Edition), 2006

I. INTRODUCTION

Laboratory rats are one of the most commonly used species for biomedical research, second only to mice. Developing an adequate institutional animal care and use program requires that the institution's occupational health and safety program perform risk assessment at the interface between humans and rats. The human-rat interface must be characterized for the presence of risk agents that may adversely affect human health. Notable examples of risks that are intrinsic to the rat are its potential to inflict bite or scratch wounds, transmit zoonotic diseases, and shed allergens. Risk modifiers intrinsic to the human are determined by an individual's general health, immune competence, existing allergies, propensity to develop new allergies, and technical competence in handling laboratory rats. There are extrinsic factors introduced at the interface inherent to the experimental paradigm that may include administration of carcinogens, toxins, biological hazards, viral gene therapy vectors, radioisotopes and/or physical hazards (for example, electricity and laser light). There are ergonomic hazards for animal care personnel associated with the repetitive movements executed when performing animal husbandry leading to carpal tunnel syndrome and/or back strain. The design of buildings, animal facilities and animal caging can be engineered to mitigate the exposure of personnel to some risks inherent to working with laboratory rats.

Minimizing risks during human-rat interactions requires an overall assessment of risk agents and risk modifiers. Risk assessment requires determining the source and nature of the risk to humans, the frequency and duration of human exposure, and the intensity of the exposure. Risk assessment examines engineering controls and operational practices for their ability to minimize aerosol exposure and to limit the contact of humans to risk agents. Occupational risk of exposure is associated with provision of animal husbandry, cage washing activity, colony management, veterinary care, facility management and research activities. A comprehensive occupational health and safety program implements adequate controls at a variety of levels: administrative, physical plant engineering and maintenance, animal husbandry equipment, personal protective equipment and periodic assessment of employee health. Additionally, consideration must be given to second-hand exposure to non-research personnel to risk agents because of their job requirements (for example, facilities maintenance personnel, housekeeping personnel, administrative personnel) or by association with coworkers that passively transfer hazards on their soiled clothing, hands and equipment. The dynamics of how various administrative areas in an institution interact as part of a comprehensive rodent exposure program can be found elsewhere (National Research Council, 1997). The purpose of this chapter is to cover many of the risk agents to consider during development of an occupational health and safety program in a research facility that uses laboratory rats. It should be noted, however, that at this point in time specific pathogen-free laboratory rats are used in the vast majority of research in rats. Therefore, concerns regarding zoonotic disease transmission are almost exclusively associated with studies of feral rat populations or research purposefully inoculating rats with known biohazardous agents.

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Nutrition of the Laboratory Mouse

Merel Ritskes-Hoitinga, ... Lars Friis Mikkelsen, in The Laboratory Mouse (Second Edition), 2012

Introduction

Laboratory mice and rats have always made up a large percentage of the total number of animals used for biomedical research purposes. This percentage is usually around 80–90% of the total number of animals used. For this reason, these species have been well-characterized in many ways. The use of the laboratory mouse (Mus musculus) has increased even more dramatically over the last decades, due to the possibility of studying gene function in vivo by the use of genetic modification techniques which have resulted in many newly established mouse strains.

The nutrition of the laboratory mouse (and rat) has also been well-studied and well-defined in comparison with that of other species (for an overview see [1]). This chapter concentrates on important aspects of feeding laboratory mice. One needs to be aware of how nutrition and feeding as an environmental factor can interact with experimental results and animal welfare when nutrition is not the main focus of study. Moreover, when the mouse is used as an animal model for human nutritional conditions, specific experimental conditions need to be taken care of. This is important in order to obtain reliable experimental results and optimal welfare of the animals simultaneously.

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The Skin and Subcutis

Jyoji Yamate, in Boorman's Pathology of the Rat (Second Edition), 2018

3 Infectious Diseases

Laboratory rats used in toxicologic studies are kept under pathogen-free conditions and infectious agents should be absent. However, while the rats are kept under conventional conditions, infectious diseases may occur. Trichophyton spp. and Microsporum spp. dermatophytoses may infect rats. At the infected sites, alopecia, crusting, and dermatitis are seen, although most infections are subclinical. Dermatophytes are recognized as arthrospores and hyphae within the hair shafts of the infundibulum. Causative agents are readily stained with periodic acid Shiff (PAS). Rats are susceptible to Demodex infection The longitudinal mites are easily detected within the follicular infundibulum with perifollicular inflammation.

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Parasitic Diseases

David G. Baker, in The Laboratory Rat (Second Edition), 2006

I. INTRODUCTION

Laboratory rats may serve as hosts for a wide variety of parasites. Although most of these infections are clinically silent, some may result in severe disease. At the least, infections may affect host physiology, and therefore serve as unwanted variables in research. Consequently, only rats free of parasitic infections are entirely suitable as research subjects. Fortunately, advances in animal husbandry have resulted in a dramatic decline in parasitic infections in laboratory rats. This is particularly true for parasites requiring multiple hosts for completion of the lifecycle. In fact, parasites other than pinworms are uncommonly found associated with rats in the modern vivarium. However, wild rats may at times gain access to and contaminate animal facilities, as well as feed and bedding storage areas. Also, animal care personnel may privately and unknowingly purchase pet rats infected with parasites. Thus, the laboratory animal professional should be aware of those parasites capable of infecting the laboratory rat. This chapter reviews those parasites that may be found infecting laboratory rats. The information has been arranged primarily according to organ system(s) involved, and secondarily by parasite phylogeny. Each parasite is presented with a brief morphologic description, lifecycle, pathobiology, diagnosis, treatment, prevention, and control.

Treatment of parasite infections deserves a special word of caution. It is well known that many drugs used to treat parasitic infections or infestations have themselves the potential to alter host physiology. In so doing, these drugs may compromise the usefulness of research animals, including rats. Fortunately, the decline in prevalence of parasitic infections in laboratory rats has been accompanied by a decline in the use of parasiticides. However, the discovery of parasitic infection in laboratory rats will require action. At times, parasites may be removed chemically without affecting the usefulness of rats as research subjects. At other times, the needs of the research study will preclude the use of parasiticides, and necessitate non-chemical methods of parasite elimination, such as cesarean rederivation. To determine whether parasiticides are safe to use in specific situations, the laboratory animal professional should be aware of the physiologic effects of commonly used anti-parasitic compounds. Relatively few such agents are used to treat rats. Among those in use, thiabendazole has nonimmunosuppressive anti-inflammatory properties in rodents (Van Arman et al., 1975). Levamisole has been used as a broad-spectrum anthelminthic in both human and veterinary medicine. It has been shown to have numerous in vivo and/or in vitro effects on rats or rat cells. These effects include superoxide scavenging (Schinetti et al., 1984). antagonism of gastric ulcers caused by necrotizing and anti-inflammatory agents (Evangelista et al., 1984), enhancement of gastrointestinal absorption of some compounds (Utsumi et al., 1987), inhibition of platelet aggregation (Pinto et al., 1990), upregulation of pyruvate dehydrogenase and glycogen synthase activity in rat adipose tissue (Thomaskutty et al., 1993; Basi et al., 1994), inhibition of skeletal tissue mineralization (Klein et al., 1993). inhibition of fibroblast collagen synthesis (de Waard et al., 1998), decreased post-surgical translocation of bacteria (Cetinkaya et al., 2002), immune stimulation (Trabert et al., 1976), and others. Fenbendazole causes far fewer effects. In rats, these appear to be limited to subtle changes in behavioral performance in young rats from dams fed fenbendazole during pregnancy (Barron et al., 2000), although other minor effects have been demonstrated in other species. Albendazole, another benzimidazole with anthelminthic properties, is embryotoxic in rats, induces drug-metabolizing enzymes in the liver (Souhaili-el Amri et al., 1988), and delays rat brain microtubule assembly (Solana et al., 1998). Lastly, ivermectin, a macrocyclic lactone disaccharide and member of the avermectin anthelminthic family, is not without its effects on rat physiology. This is important considering the common use of ivermectin in the treatment of parasitic infections in rats and other host species. In rats, ivermectin and doramectin, another avermectin, are known to possess anxiolytic effects (de Souza Spinosa et al., 2000, 2002). Still other members of the avermectin family may be selectively cytostatic against tumor cells (Driniaev et al., 2001). Lastly, the avermectins may cause developmental neurotoxicity in rats (Poul, 1988; Wise et al., 1997). Each of these reports highlight the potential for commonly used anthelminthics to alter host physiology.

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Norbormide

L.P. Weber, in Encyclopedia of Toxicology (Third Edition), 2014

Animals

Laboratory rats showed difficulties in locomotion and ataxia but no hind limb paralysis after treatment with norbormide. Death occurs within 15 min to 4 h after struggling, dyspnea, hypothermia, and convulsions. Oral lethal dose 50% (LD50) values for Norway rats ranged from 5.3 to 15 mg kg−1. Rodents other than rats have considerably higher oral LD50 values (e.g., hamster, 140 mg kg−1; guinea pigs, 300 mg kg−1; and mice, 1000–2250 mg kg−1). However, no effect was detected with 1000 mg kg−1 doses of norbormide in dogs, cats, monkey, sheep, pigs, chickens, mallard ducks, and prairie dogs. Interestingly, L-type voltage-dependent calcium channels in guinea pig heart were relatively selectively inhibited by norbormide in the sinoatrial and atrioventricular nodes, suggesting a possible therapeutic benefit for norbormide in treating supraventricular arrhythmias in heart failure.

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Taxonomy and Stocks and Strains

Hans J. Hedrich, in The Laboratory Rat (Second Edition), 2006

Publisher Summary

The laboratory rat has long been used in experimental physiology and has made significant contributions to several complex areas of mammalian biology. This chapter presents the taxonomy of laboratory rat and discusses its stocks and strains. Rats are rodents, and thus members of the largest family of mammals. Approximately 1,325 living species of murid rodents have been described by now, the members of which are currently placed in 281 genera distributed among 17 subfamilies, and which include most of the familiar rats and mice. Stocks and strains of laboratory rat discussed in the chapter are outbred stocks and inbred strains including standard inbred strains, coisogenic and congenic strains, consomic strains, and recombinant inbred strains. A key feature of rat nomenclature is the laboratory registration code, whether it is for the definition of an outbred stock or an inbred strain. This code is usually three to four letters, and identifies a particular producing institute, laboratory, or investigator. Further, these codes are intended to identify outbred stocks and inbred strains, including congenic strains.

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The Alarm Phase and the General Adaptation Syndrome

R. McCarty, in Stress: Concepts, Cognition, Emotion, and Behavior, 2016

Sensitization

When laboratory rats are exposed to a high-intensity stressor, there are recurring alterations in cardiovascular and metabolic homeostasis. One such stressor that has been studied is immersion of laboratory rats in water maintained at 18 or 24 °C for 15 min per day for 27 consecutive days. When compared to controls exposed to swim stress for the first time, animals exposed to chronic intermittent swim stress had significantly greater elevations in plasma levels of NE and EPI. This sensitized response of the sympathetic-adrenal medullary system to chronic intermittent swim stress is dependent on stressor intensity (i.e., water temperature). In contrast, chronic intermittent swim stress in water at 30 °C results in habituated plasma catecholamine responses.

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Developmental Neurotoxicity of Abused Drugs

Brian J. Piper, Jerrold S. Meyer, in Reproductive and Developmental Toxicology (Second Edition), 2017

Species Considerations

Laboratory rats (Rattus norvegicus) and mice (Mus musculus) are the most commonly used animals in developmental neurotoxicity studies involving drugs of abuse. Both species are relatively inexpensive, can be bred readily in the laboratory, and have a short gestation period and rapid postnatal development. Investigators using rats or mice can avail themselves of an enormous existing literature on fetal development, neuroanatomy, neurochemistry, molecular genetics, and behavioral characteristics of both the animals. Genetic engineering of mice affords an additional powerful tool to examine mechanisms of developmental neurotoxicity, although this approach has not yet been fully exploited by the field. Despite all the important advantages of using a rodent as opposed to a primate animal model, there are also a few disadvantages that should be kept in mind. First, as mentioned earlier, rodents are not as suitable as primates for testing higher cognitive functions. As Paule et al. (1990) have elegantly demonstrated, it is possible to design cognitive test batteries that directly probe the same functions in monkeys as in children, and such test batteries have been used to investigate the effects of prenatal exposure to drugs of abuse and other potential toxicants on cognitive function (Morris et al., 1996). Second, because development is so much more rapid in rodents than in humans, it is necessary to adopt an appropriate translational approach in selecting the period of drug administration for modeling human gestational exposure. Early methods for equating brain maturation in rodents (mainly rats) to that of humans relied primarily on neuroanatomical comparisons at specific points in fetal or postnatal development (Clancy et al., 2001, 2007a). However, Clancy et al. (2007b) have now developed a web-based neuroinformatics approach to the extrapolation of brain development across 10 different species: hamsters, mice, rats, rabbits, spiny mice, guinea pigs, ferrets, cats, rhesus monkeys, and humans. The computational algorithms use days post conception as the time measure, and separate extrapolations are provided for cortical development, limbic system development, and development of noncortical/nonlimbic brain areas. For example, 20 days post conception in mice (equivalent to roughly 1 day postpartum in this species) translates to approximately 124, 90, and 97 days post conception for the development of cortical, limbic, and noncortical/nonlimbic brain areas, respectively, in humans. Consequently, administering a drug of abuse to newborn mice can be expected to influence neurodevelopmental events that occur during the second trimester of human pregnancy.

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"With this, the blood familiar is now only under your command and has no connection with the Academy, this is one of the services the Academy provides to the new apprentice's, the familiar can be used as a scout and also to send an emergency message during risky missions" after saying that the old man took out the token from the bowl and tossed it towards Wade.

" Now you can take back your token the contract between you and the academy has been fully settled, you can only break away from the contract by two methods.

First, if the academy breaks it after your period of studying inside the academy is completed with is usually after 10 years.

Second, you break through the 5 rank apprentice realm and break it from your side, as for the information that the academy was giving you through the familiar it's job will be taken by the crystal ball that we provided you as it's function is the same as your modern phone, do you understand till here?" the old man asked after explaining the academy's contract in short.

"Yes Sir!" Wade answered.

Nodding the elder rummaged through the shelves behind him before looking towards Wade and said, "Take this! A set of acolyte robes and an identity badge! A crystal ball which contains an elementary meditation technique and keys to your room containing its number is there too!"

The old man threw the black sack containing the items to Wade, and then snapped his fingers. *Bang!!!* A brown doll suddenly formed from the dirt in the room and floated in midair.

"Follow this earth golem, it will bring you to where your mentor is!"

Then the old man made a gesture to send him off, and Wade quickly followed the golem.

The golem was in front, and would occasionally spun in a circle. Its speed was too slow and with Wade's body, he was getting bored because of such speed.

 From time to time, there were people in black robes passing, but they did not look at Wade in astonishment.

Wade followed the dirt golem and passed through several corridors, large halls, and a huge pond. It then stopped in front of an area designed for experiment labs.

The dirt golem turned into fine dust, and immediately passed underneath the door, leaving Wade alone outside.

Wade was helpless, yet he did not dare knock on the door, so he just waited outside patiently.

After a moment, there came a middle-aged man's voice.

"Wade, huh? Enter!"

"Yes!" Wade pushed opened the doors of the experimental lab. A ripe and sour aroma filled the laboratory room, mingling with the odour of rot and various poisonous liquids, which made Wade fell at home.

A gigantic metal table took up the space of almost half the lab, and placed on it were various organs, skulls and blood, as well as some other apparatus that Wade could not identify, this made him recall his previous life experiments.

In front of the laboratory table, there stood a middle-aged man,  half his face was white skeletal, while the other was normal he wore a black robe. His collar was embroidered with red patterns, and his eyes emitted a blue light, like two oceanic gems.

"I'm Fred, and I've heard about the arrangement from the crystal ball. So then, Wade, are you willing to become my apprentice?" The middle-aged skeletal man put down the skull in his hands and said while giving a bright smile towards him which almost spooked Wade because of the atmosphere.

"I am willing!" still Wade answered without any hesitation.

"That's good! Since these are the arrangements made by the academy, so I'll accept you as my apprentice!" The middle-aged skeletal man stroked his beard.

"Although the environment here is relatively gory, it's enough to let you undergo the procedure!" Fred swept his eyes over the examination room. "At least it's very quiet here and we won't be disturbed!"

"What procedure?" Wade had some doubts.

"The procedure to start on the path of Sage!" Fred replied.

replied.

"Now tell me, Wade, what is your understanding towards Sages?"

"An unusual person with the ability to call forth snow and storm, manipulate flames and other forces of nature!" Wade said the definition he understood from Larry's books.

"En! However, it's a little off!" Fred stated.

"A Sage is actually the title we give to people with ability in chronological times. These Sages all learn the laws of nature and how to control and manipulate the energy within. They are never-ending in their pursuit of knowledge and truth no matter the cost for it!"

Fred explained the definition of Sage to Wade.

"So it is to say, the title of Sage is actually not limited to only humans!" Wade had a better perception now.

"Indeed! Other kinds of demi-humans, and even other intelligent beings, have Sages existing among their kind, for example, a Sage of the forest tribes, even we are not from the Sage world are known as Sages"

" Mentor, do you mean our world is another world under the Sage world?!!" Wade was quite shocked by this discovery as this world was already 10 times big than his previous world, he couldn't even imagine the size if Sage world.

"Yes, this world is just another world that has been taken over in the ancient times by those powerful Sages, you know that the other half of the planet cannot be explored by any means by humans. 

The reason behind this is that some of the Rank 2 and Rank 3 Sages had fought there before and caused that side to become inhabitable for normal humans." Fred said reminiscing about something.

After a second or two Fred said, "Alright! Now let us begin the ritual! Don't be afraid and lie down, it's a very simple procedure!"

After rummaging around Fred found a flask from the drawer in the table, and then using it he drew on Wade's body some sort of spell formation, and slowly a strange energy came spreading from within the formation.

The surroundings turned dark, with only the flame lit in the centre of the formation.

Like the surge that subsides after it's time, the era of Gods and Devils is returning, 
how far will a person go for his ideals in this mystical epoch?


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The 01 Guerillas were still in shock. Although Black Nest had dispatched snipers at the ski resort last time, they weren't under fire at that time, and so, the fear was simply surreal to them. When the sniper killed Iron Fist, his blood splattered all over Zhang Heng's shirt. It made them realize that they had just crossed paths with death himself.
Everyone, including Leah, crouched under their seats, fearing that the flying bullets would claim their lives from nowhere. Two minutes later, Zhang Heng told them, "Okay, you can come out from the hiding. We are safe for now."
"Uhh... are you sure? I heard that he could snipe the farthest. How far did he shoot when he was being deployed at the ski resort?"
"We are in a city now, not an open environment like a ski resort," Zhang Heng explained patiently, "The route I chose has a building as cover. The snipers can't shoot us from here."
"That's a relief.." Waldo finally relaxed and returned to his seat.
Although out of danger, Ponytail wasn't looking too good. "Those people are not targeting us. Their target is Edward. Black Nest's patience is finally running out, and they do not intend to use peaceful means to resolve this matter."
"Edward is in a dangerous situation now. We must find him before they do." Semiprime said in a rare occurrence that he spoke up. 
"But the only person who knew his whereabouts has just died in front of us."
As soon as Little Boy said these words, everyone fell silent again. Although still less than forty, Ponytail was the oldest among the team, and he'd never faced a life and death situation before. Ever since he got himself involved in Black Nest's and Edward's matter, he had witnessed death twice.
When Ponytail jumped down from the bridge, he survived miraculously somehow. However, Iron Fist was really dead this time. There was no way that he could survive that fatal shot.
"I've been thinking about a question along the way: how did Black Nest find us here?" Philip, who had not spoken in a while, asked.
"Eh?"
"No one knows Edward's abilities better than us, but the guy who died just a few minutes ago said that Black Nest raided their residence two weeks ago. Judging from Edward's character, he would only become more cautious. At the same time, he must have found out the reason behind it and took precautionary measures. But even so, Black Nest still managed to locate him two weeks later."
"Are you trying to say that someone betrayed Edward?" Little Boy raised her eyebrows, "At a time like this, there are not many Edward can trust. Iron Fist is definitely not the one that betrayed him. After all, he is already, uhh... that way. So only Mr. Gilm is left, but considering what happened to his son's family before, it is unlikely he's on Black Nest's side."
"I'm not saying that there is a traitor among us, but that there must be something that allowed Black Nest to locate Edward," Philip sighed, "unfortunately, we don't know what that thing is."
"It's CTOS," Zhang Heng, who was driving, interrupted suddenly.
"Eh?"
"Black nest has connected CTOS to this city."
01 looked at each other when they heard that, "...it's impossible, isn't it? CTOS isn't even complete yet. And generally speaking, such a project needs to be approved by the House first."
"Certain parts of CTOS have yet to be completed, and the algorithms haven't been calibrated to their optimal level as well. However, the part of the system that collects personal data from the public was completed half a year ago. In theory, this toned-down version of CTOS is now online. As for its legal jargon, Black Nest didn't get authorization from the parliament, but they are very powerful in Toulouse, and the city council is theirs. They've obtained a signed document from the mayor, allowing them to carry out some 'preliminary experimental work' in Toulouse."
"What preliminary experimental work?"
"That's where the problem lies. The definition of the phrase isn't stated clearly in the document. That would mean Black Nest can do whatever they want at this point."
"Including silently launching CTOS without the public knowing it?" Leah's eyes widened.
"It seems like it."
Before leaving the parallel quest, Zhang Heng wanted to figure out what exactly the number zero meant in the main mission. He did not get the answer from 01, and Edward's murder didn't yield too much useful information either. Zhang Heng spent half a month visiting people involved in the matter at that time, and he did not get anything useful from them. After that, he sneaked into Black Nest's headquarters on the last day and found a copy of CTOS's development records during its early days. According to the research and development records, Black Nest apparently launched an unfinished version of the CTOS system in secret to capture Edward.
The name of this system—Zero.
However, according to information Zhang Heng collected, Zero was only supposed to be launched two weeks later. Zhang Heng still had plenty of time to do the necessary preparations. Zero must have gone online earlier than scheduled because of the players' behavioral changes.
Two weeks ago, Black Nest people raided Edward's room, proving that Zero must have been online at least one month earlier.
"Okay... we now face a city under close surveillance of Black Nest," Philip took a deep breath, "let me think about what we can do at this time?"
"Can you hack into the CTOS system?" Ponytail asked Waldo.
"I don't know. Edward once talked about CTOS with me. He and several other talented guys developed their advanced AI security, a system which continuously improves itself through machine learning. He boasted that even he couldn't hack into it. But you know me, I never thought that there are places in this world I could never go. It will take time, maybe weeks, maybe months, but they will eventually track me down. No... I should say, with the help of CTOS, they will track us down inevitably."
"I can hack into CTOS," Zhang Heng said, "but of course, my skills are only good enough to hack into the incomplete CTOS."
In the parallel quest, a group of hackers led by 01 fought a long war with Black Nest. During this period, the hackers had managed to achieve some small gains. However, every time they found a loophole, Black Nest would upgrade CTOS' security. In the end, the hackers had inadvertently made CTOS more perfect than before. It was nearly perfect, in fact, which was the group of hackers was in such a rut in the end.
But this wasn't the future. Zero was the early version of CTOS, and it surely had loopholes. Two months before they entered the small town, Zhang Heng was already more prepared than everyone in the 01 Guerillas.


Growing up with eccentric materialistic parents who left him in the care of his grandfather for a job overseas, Zhang Heng had learned to adapt and be unfettered by the oddities and challenges in life. But he would soon learn the baffling truth about the world he thought he knew when one day at midnight time froze and he found himself in a world so quiet and still it was deafening. That night, he discovered that he had 24 hours more than everybody else and thus, marked the beginning of his adventures. The mysteries surrounding his newfound ability only deepened when a strange old man claimed to have given Zhang Heng that ‘gift of time’ and recruited the young man to participate in a cryptic ‘life-changing’ game on his behalf. Little did Zhang Heng know that accepting those terms meant embroiling himself in many versions of reality and exposing himself to the hidden secrets of the world—a decision he could never undo.



“Big bro, let me bring him outside and beat him up.” 

“No,” Gorou chided. 

“Don’t I tell you to always watch that temperament of yours?” 

It upset Daitaro when he heard this, but dropped his attitude. 

They had inherited a bad temper that was a trait passed on in their family. Even the women in the family were fierce. 

“Besides. You think I’m going to let them humiliate us with this?” 

Daitaro became confused. 

“What do you mean?” 

“Hmm.” 

Gorou thought a bit to make sure if it was okay to tell him, but it wasn’t a big deal. 

“Rumor is there’s this experimental drug that the military has been researching.” 

The topic seemed to have gone from point A to point C. Daitaro was the definition of brawn over brains so his eyebrows bending was a sign of his CPU overclocking. 

“You saw that guy’s ‘magic trick’ right?” 

“Yeah, so?” 

“That military drug is a performance enhancer.” 

“Hoh.” 

“I didn’t think they’d get their hands on it quicker than we did.” 

The higher-ups didn’t jump on board because they needed more information about this drug and if it was profitable. Since they’re primarily trafficking methamphetamine. 

The drug was also hard to smuggle from the military. 

The Taiwanese must have been trying to monopolize a new drug as they were lacking in that department because of the Yakuza’s capital on illegal drugs. 

“So what are you going to do then?” 

“I’m going to torture the information out of him then hold him for ransom.” 

“Huh? Didn’t you say something about not starting a war?” 

“I was telling you to think before you act and don’t do things without your boss’ go.” 

“Ouch!” 

Gorou knuckled his Lil brother in the head. He was over 2 meters tall while Daitaro was 1.8 m. 

“If he really came here by himself. It isn’t a big deal. And look, he’s wearing a school uniform. He’s either a pup or an uninitiated wannabe.” 

If Hikaru was the son of an important person, they wouldn’t have sent him to enemy territory. He wouldn’t be taking experimental drugs either. 

The higher-ups don’t take the drugs they deal because of its addictive qualities. When you’re rich in a crime syndicate, you’re only interested in making more money, gaining more power and living a prosperous life. 

Since having a stress-free and long life span was rare in the life of crime. 

Also, a regular kid couldn’t afford it, so the only reason they gave him it is that he’s a test subject to make strong foot soldiers. 

“But if he’s useless, then who would pay the ransom?” 

“If no one does, I’ll just kill him.” Gorou grinned. 

Even if the Triad gang members weren’t happy about it, the higher-ups certainly won’t allow a war to start. It wouldn’t be profitable. 

The key thing is Hikaru wasn’t even worth a single ab machine in this gym. 

Daitaro smiled as well. 

“Hah! CAAHHH-” 

“Oh, shit!” 

They both turned to look at the commotion. 

A guy was being crushed under a barbell on the bench. His arms were bent against it as he tried to lift it off. Some guys rushed over and lifted it for him. He was coughing and wheezing. Then he spat out that he needed the hospital. 

The guys called the ambulance, and it came within 10 minutes. 

They put him on a stretcher and carried him away. 

Gorou shook his head outside the gym as he watched the ambulance leave. 

*** 

Pectoralis major, trapezius, deltoids, serratus anterior, triceps, latissimus dorsi, sternocleidomastoid etc. Hikaru could feel the muscles that were damaged. 

He could “see” the tears in the muscle fibers. He could tell the bones that were cracked and strained. Not only that, but he could see them mending themselves. 

‘It’s like I can sense the structure inside me in explicit detail. As if I developed internal spatial awareness? Could it be…’ 

That time when Genkei, the parasite neighbor who came to his doorstep had touched the skin of his neck, he sensed that Genkei’s cells were not human. 

‘So, my cells have become extra-sensory?’ 

This ability was possible because he was made up of parasite cells that mimicked human tissue cells. 

Just like how his ears had morphed into hairless cat ears, the parasite cells have mimicked muscles cells, bone cells, skin cells and every other cell type that originally filled his human body. 

The parasite cells have this ability to send Hikaru intracellular and intercellular environments as spatial data that is transmitted to Hikaru's brain and then reconstructed into a 3-dimensional image that he can scrutinize. 

Hikaru sat on a leg press chair while he was waiting for his upper body to heal. 

Hikaru’s body, as it is, was weak and wouldn’t handle large amounts of load and pressure. 

Bodybuilders don’t just have bigger muscles, they have stronger bones, joints, tendons, and cartilages. The strengthening of the body takes lots of time and effort. 

Hikaru was reinforcing his body by adding more biomass to his musculoskeletal system. 

He strengthened his joints, tendons, cartilages and increased bone density. His wounds have healed over, and now he was waiting for his body to catch up with the exercise. 

Meanwhile, he was eavesdropping the conversation outside. 

*** 

“So how do you want to torture him?” 

“You leave that to me. You’re grounded remember?” 

Daitaro didn’t forget being grounded by his father and he had to get ready for the pop quiz tomorrow. 

Although he could pass school with money, the father wanted him to be smarter for the sake of earning a leadership position in the Yakuza. 

After all, half of their business was out in the public. They need some level of intelligence to run businesses. 

Daitaro hoped Gorou would bail him out tonight for some ‘important Yakuza business’ 

“Ass,” Daitaro replied. 

Daitaro peered into the gym through the glass wall and saw Hikaru sitting on one machine. 

“I think he wants to fight with you. You think you can take him alone?” 

He thought Hikaru might be dangerous since he could bench press as much as he can. 

“He’s unarmed. Hmph. He’s still a small fry to me.” 

Gorou could lift more than twice as Daitaro can. He had made one of the highest bench press records internationally.

An alien parasite inside a cat ambushes Hikaru. Unbeknownst to it, he's a psychopath who killed his mother and can reverse-hack the parasitic cells, taking its body and powers for himself. Evolving from absorbing other living organisms, he begins changing as he becomes sensitive to emotions. Ironically, an alien made him more human than ever. Dragged into an ever-growing war between parasites and humans, will Hikaru become the dark hero humanity needs? Or will he fulfill his dream of world domination?

At the same time, the Master System and its power are in peril as a result of Hikaru's actions. A simple nobody named Elijah reincarnates with the Hero System and is sent back in time to restore order to the universe.

Read between the Dark and light chapters of Parazyte, explore the Naruto and Sasuke type dynamic of the two characters, the vast world-building and in-depth character development with rich side characters (sprinkled with 2D characters for fun). 

Warning: Book recommended for 18+. Realistic violence and death is the theme. Hero chapters are sometimes light-hearted but often contain sad realities.

The world shakes under their overwhelming power. The fate of the world depends on who becomes a God. 

Readers from a parallel universe can affect the storyline with their quantum tremors.

experimental definition novel

Experimental Errors

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Experimental Reincarnation

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The Shadow Within

Dairies of a lost soul; Beyond Boundaries.

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48 Hours a Day

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