The screech radiated pain that all Men, despite understanding, could not truly relate to, at least the vast majority that had not yet had the displeasure of losing their balls.
Melinda did not stop at just piercing her cousin's family jewels but also, through her sword, caused a mini explosion that ruptured the organ as well as the nuts in a sack completely.
"Let's get rid of it in the entirety. The last thing we want is for it to be healed again" Melinda said and she was mostly the one supporting Cirk's flight.
Melinda's words were referring to the incident that sparked the start of her hatred for Cirk when she first cut off his family jewels but they were promptly restored once she had been exiled from her family. With this explosive rupture, made permanent by her ordinant might, no way could that be the case again.
Cirk's screech was restarted after that explosive rupture and the pitch increased to the point where he sounded like a tortured swine.