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Ivan received the attack from Lucia head-on, as he covered himself on his large shield made of his bony growths coming from his arms!
BOOOMMM!!!
Lucia noticed that her flames were not able to calcinate such strong bone structure, a growth made by the power of Uroboros.
Uroboros was the super evolved form of the Virus Z, with the power to regenerate flesh and also to shape it, to form mutations at will through provoking cancerous deformities in the body, however, unlike mutants, the user was able to also heal these cancerous growths at will, being able to easily use them as weapons that can retract.
There are many types of cancers and viruses capable of forming all sorts of tumors through the duplication of malign cells, Uroboros uses this logic to enhance Ivan Wesker's capacities beyond a human through the ability to shapeshift his body into amorphous forms.