Doctor Octopus is also a likely candidate. His mechanical arms and high intelligence could give him an edge. He could manipulate a situation where Peter is caught off - guard and unable to defend himself, resulting in his death.
In some fanfictions, Peter might die heroically while saving the city from a powerful villain like Venom. He could sacrifice himself to protect his loved ones and the innocent.
Well, one possibility is that a new hero could emerge in his place. Maybe one of his friends or a previously unknown character with powers would step up to protect the city. For example, Miles Morales could become even more prominent earlier than in the regular storyline. The city would be in chaos without Spider - Man, so the police might have to step up their efforts in a new way.
One great fanfiction idea could be that Gwen discovers Peter's secret identity in a really unexpected way. Maybe she stumbles upon his Spider - Man suit while looking for something in his room. This would create a lot of drama and tension between them as she has to decide what to do with this knowledge.
He could become more withdrawn. Losing Aunt May, who was like a mother to him, would be a huge blow. He might isolate himself from his friends and even from his crime - fighting duties for a while as he deals with his grief.
Well, it would change him a great deal. He'd probably go through a period of intense grief. This could lead to him isolating himself from his friends like Ned. However, he'd also realize that Aunt May would have wanted him to keep being Spider - Man. So he'd start to focus more on the big - picture threats to the city, rather than just small - time crime. His motivation would shift from just doing the right thing to honoring Aunt May's memory.
If it's a crossover with the Fantastic Four, perhaps a cosmic entity is attacking Earth. Spider Man teams up with them to stop it. But during the battle, he's exposed to some deadly radiation from the entity. Despite the Fantastic Four's efforts to save him, his body can't withstand it, and he dies. His death could lead to the Fantastic Four creating new safety protocols for future battles.
One possible scenario could be that Spider Man sacrifices himself to save the city from a powerful and unstoppable villain. He might use all his strength and powers to defeat the enemy, but in the process, his body gives out due to the extreme exertion.
Well, often in 'Spider - Man: Homecoming' fanfiction, Peter's Spider - Sense is used in creative ways. It could be tied to his growing up process. As he matures, he learns to better control and interpret his Spider - Sense. Maybe it starts to work differently around his friends, like it gives a softer signal when they playfully surprise him compared to a full - on danger alert.