Often in such fanfictions, the plot may involve a betrayal that pushes Harry over the edge. It could be a friend or a mentor who turns on him. This sudden shift in loyalty would shatter his world view. He has always relied on the support of those around him, and when that is taken away, it becomes difficult for him to stay sane. His actions would then become erratic as he struggles to come to terms with this new and cruel reality.
Maybe Orochimaru manages to get his hands on Naruto and subjects him to some dark and twisted experiments. These experiments could mess with Naruto's mind, causing him to lose his sanity. He could start seeing illusions all the time, believing his friends are his enemies. As a result, he'd be in a constant state of confusion and aggression, and his once - positive attitude towards life and ninja - hood would be completely gone.
Perhaps an unknown and powerful dark ninja. This ninja could be from a long - forgotten clan with dark powers. They might have a vendetta against the Leaf Village and see Naruto as the key to their revenge. So they use their dark arts to make Naruto lose his sanity and turn him against his own village.
It could be that Naruto discovers some dark secrets about his past, like his parents were actually killed by the very people he trusted in the village. This revelation is so shocking that it shatters his mental state. He becomes a completely different person, losing his sense of right and wrong, and his sanity along with it.
It could be Kaguya. If Kaguya were to return and use her powerful abilities to drive Naruto mad, perhaps by invading his mind with dark thoughts and memories. She has the power to warp reality and minds, so she could easily make Naruto lose his sanity. And since she has a grudge against the world of ninjas, making Naruto, one of the most powerful ninjas, go insane would be a great way for her to start her reign of terror all over again.
Obviously, Harry Potter himself is the central character. Since the story is about him losing his sanity, he is at the core of the plot. Then there would likely be his friends like Hermione and Ron. Their reactions to Harry's deteriorating mental state would be important aspects of the story. They might try to help him, or they could be at a loss about what to do.
He attempts to prove his sanity by explaining his motives in great detail. He claims that it was the old man's 'evil eye' that drove him to commit the murder, thinking that by providing a reason, it shows he is in control of his actions and thus sane. However, his over - the - top explanations actually do the opposite and make him seem more unhinged. He also mentions how methodically he dismembered the body and hid it under the floorboards, believing this orderliness is evidence of his sanity.
One possible plot could be that Naruto's loss of sanity causes him to have a distorted view of the Fem Kyuubi. Maybe he sees her as both a threat and a source of power he can't control. This could lead to a conflict within himself as he battles his inner demons while also interacting with the Fem Kyuubi in unexpected ways. For example, instead of the usual relationship of cooperation or taming, he might try to completely dominate her, which would be a big shift from the normal Naruto we know.
Twin Sanity is purely imaginative. It's not drawn from real-life happenings. The story and characters are crafted from the author's creativity rather than real experiences.
Harry might maintain his sanity through his memories of Hogwarts. The thought of his friends, the magic he has learned, and the happy times at school could be his mental refuge. For example, he could recall the fun times in Potions class or flying on his broomstick during Quidditch matches.