Ichigo could be a game - changer. His Hollow - like powers might be mistaken for some sort of demonic or otherworldly ability in the Highschool DxD setting. This could lead to both misunderstandings and interesting interactions with the characters there.
One possibility could be that Ichigo's powers would make him a very unique and powerful character in the Highschool DxD universe. His zanpakuto abilities and high - level combat skills could give him an edge in the battles against the devils and other supernatural beings in that world.
A fanfiction could focus on Ichigo attending the school in Highschool DxD. His presence would surely disrupt the normal balance. He might not be interested in the whole 'devil' and 'angel' thing at first, but gradually get involved. He could also introduce some of his Soul Reaper training methods to the students there, which would be very different from what they're used to.
First, you need to understand the characters well. For Ichigo, know his personality traits like his determination and his sense of justice. For the Highschool DxD characters, understand their hierarchies and their goals. Then, come up with a unique plot. It could be a battle - oriented story where Ichigo and the DxD characters fight a powerful enemy together. Or it could be a more slice - of - life story where Ichigo adapts to the strange new world of DxD.
The characters in DxD would be quite shocked at first. Ichigo's appearance and his powers are so different from what they are used to. For example, Rias Gremory would probably be intrigued by Ichigo. She might try to form an alliance with him, seeing his potential as a powerful ally. Issei, being the main character in DxD, would likely be both jealous and in awe of Ichigo's abilities, and might challenge him at first but then learn from him over time.
A third idea could be a time - travel fanfiction. For example, a character from Highschool DxD travels back in time to the era of Bleach and meets Ichigo when he was still developing his powers. This could lead to some interesting interactions and changes in the timeline of both universes.
Issei would probably be the first to want to fight Thanos. He's always eager to prove himself and protect his friends. He might initially underestimate Thanos due to his own growing power and confidence, but soon realize how powerful Thanos really is. Rias would be more cautious. She would likely try to gather information about Thanos first and then formulate a plan to either fight or negotiate with him.
Issei, being the hot - blooded character he is, would probably be excited to meet someone as powerful as Naruto. He might challenge Naruto to a friendly spar at first, hoping to learn from him and test his own strength. And as he gets to know Naruto better, he could start to see him as a brother - in - arms, especially if they face common enemies together.
Maybe a rogue Devil who wants to use Ichigo's power for his own gain. He could try to manipulate Ichigo into fighting against the other factions, like the Angels and the Devils who are trying to maintain the balance in the world. This Devil would be very cunning and would constantly be devising new ways to control Ichigo.
In some fanfics, a great plot twist is when Ichigo's Hollow powers are misinterpreted by the DxD characters as some sort of devilish power. This leads to a lot of misunderstandings and conflict at first. Another interesting plot twist can be when Ichigo somehow ends up being related to an important figure in the DxD world through some convoluted backstory.