The children's powers might be more focused on restoration rather than destruction. Given that they are a new generation, they could have powers that are the opposite of Thanos' in some ways. So while Thanos was all about obtaining the Infinity Stones for destruction and control, his children could have powers related to using the energy of the stones in a positive way, like healing entire planets or restoring lost civilizations.
Another storyline could be the children of Thanos being raised by the Avengers. Imagine the Avengers having to take on the role of surrogate parents. They would have to teach the children about good and evil, and the children would be in a constant struggle between their inherited nature from Thanos and the new values instilled by the Avengers.