His Pikachu would be heartbroken. Pikachu has been with Ash from the very beginning, and it would likely go into a state of deep depression. It might not eat or interact with others for a long time. Other Pokémon like Charizard would also be extremely sad. Charizard, which has a strong bond with Ash, might fly off on its own, looking for a place to grieve in solitude.
Nezuko is initially 12 years old in the manga. As the story unfolds, her age doesn't change significantly in a traditional sense, but her character development is quite remarkable.
Naruto would be devastated. He might blame himself for not being able to protect his son. Sasuke would be angry and would likely go on a hunt for the perpetrator. His friends like Sarada and Mitsuki would be heartbroken. Sarada might vow to become stronger to prevent such a tragedy from happening again.