His sense of humor might change. While he still has his quippy nature, it could be more cosmic - themed. For example, he might make jokes about black holes or alien cultures. His empathy could also expand as he meets different beings from across the universe and understands their plights.
In some fanfictions, Spider - Man might gain the ability to teleport across the cosmos. This could lead to him exploring different galaxies and encountering alien species that are both friendly and hostile. He could use his spider - sense in new ways, like detecting threats from across the universe.
Definitely Marvel. Spider-Man has been a staple in the Marvel Comics universe for a long time. His adventures and storylines are all within the Marvel framework.