Biochemical breakdown of glycogenGlycogen decomposition was a biochemical process. In the presence of an organic phosphorus acid, it was catalyze by a Phosphorylating Acid. Phosphorylating began from the alpha-1,4 glycosidic bond at the non-reducing end of the glycogen molecules, releasing glucose- 1 -phosphorus acid until it formed limit starch. Subsequently, the glucose- 1 -phosphorous acid was converted to glucose- 6 -phosphorous acid under the catalyze of the glucose mutants. Finally, it was converted to glucose under the catalyze of the glucose- 6 -phosphorous acid in the liver. During this process, the glycogen debranching-ase also played a role. It could break the alpha-1,4-glycosidic bond between the third and fourth glycosides of the four glycosides in front of the branch point of the alpha-1,6-glycosidic bond left by the glycogen Phosphorase, move the three glycosides to the end of the other non-reducing end and connect them with the alpha-1,4-glycosidic bond. It could also make the remaining alpha-1,6-glycosidic bond connected to the glycoside to be digested. Releasing one molecular sugar. Glycogen cleavage requires glycogen Phosphorase and Debranchase. Glycogen Phosphorase has different Isozymes in skeletal muscle, liver, and brain.
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Cellulose and Glycogen are biological substances.Celluloses were a type of glycan found in plants. They were the main components of plant cell walls, and they belonged to the class of glycans found in living organisms. Glycogen was a type of branched-chain glycan formed by the combination of glucose, also known as liver glycan or glycogen. It could be divided into liver glycogen and muscle glycogen. It was an energy storage substance found in animals, and it was also a class of glycogen.
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Biological Glycogen Knowledge PointsGlycogen (C H O)n, also known as animal starch, was a branched-chain glycan condensed from many glucose. It was a storage form of glucose in humans and animals.
I. Glycogen synthesis (Glycogen Formation)
1. During the resting period after the liver completes the Colli cycle, the process of glycogen production is initiated; this process can also be initiated by hormone, such as after a sugar-rich meal, which is secreted in response to the increased blood sugar level.
2. The general process of synthesizing glycogen from glucose was as follows: glucose → glucose 6 -monophosphate → glucose 1 -monophosphate → eudPG → glycogen.
II. Glycogen distribution
It was mainly distributed in the liver (liver glycongen) and skeletal muscle (muscle glycongen) of animals. Glycongen was also found in some lower plants, fungi, yeasts, and bacteria. Among them, the human liver stores about 100g of glycogen (accounting for 6% - 8% of the liver weight) to maintain the stability of human blood sugar, and about 400g in skeletal muscle (accounting for about 1% - 2% of skeletal muscle weight).
The molecular structure of glycogen
1. D-glucose, which was linked by alpha- 1,4 and alpha- 1,6 glycosidic bonds, could be completely digested into D-glucose with a molecular weight of 1 million to 10 million. It was a highly branched and uneven molecular.
2. The straight chain was mainly bound by alpha-1,4 giycosidic bonds, while the branched chain was bound by alpha-1,6 giycosidic bonds. Each branch contained 12 - 8 sugar residue. There was a branch every three sugar units on the main chain, and there were branches on the branches every three sugar units. The outermost branch contained about 6 - 7 sugar units. Glycogen had only one reducing end, but there were many non-reducing ends. Glycogen synthesis and digestion started from the non-reducing end.
The Nature of Glycogen
1. Glycogen was a white powder with a density of 1.629g/cm 3. It was not dissolved in alcohol, but it was dissolved in hot water and reacted with iodine-producing a brownish-red color.
2. Its chemical composition is very similar to starch.
Function of Glycogen
1. The main function of hepatic glycogen
- It provides glucose to maintain blood sugar levels during exercise. When muscles extract glucose from the blood for the production of Ang-3, if other sources of glucose cannot be used immediately, the blood sugar level will drop. The decomposition of liver glycogen can prevent the low blood sugar caused by exercise.
2. Muscle Glycogen's Main Function
- It provides glucose for the glycolysis in the muscles during exercise. The glucose produced by its decomposition remains in the muscles and provides fuel for the production of adenosinetrimonate.
3. Glycogen can also be used as an energy source for metabolism. The human body's intake of glycogen can improve the heart and blood circulation ability, and protect the liver.
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Seeking the metabolism of modern China societyHe recommended a few good novels. " The Self-Cultivation of the Siheyuan God of War " was a novel about urban life written by Hua Mengxuan. It was about the four lives of an idiot.
'To the Age We Struggle' was a modern romance novel written by Qing Deng Ning Jing. Everything in this society was changing, and people were also changing for the better. This was a complicated era. No matter what, they had to stick to kindness and move forward courageously. The style of writing was very realistic and not melodramatic. Those who liked publishing style could read it. There was also a book friend group.
" Tokyo's All-Professional Master " was a light novel written by Magical Lemon Tea. The male protagonist, Hai Zhui, had many female protagonists. Every month, they would change their jobs and become more and more strange. There were even daughters of tycoons who wanted to get close to the male protagonist.
Empire Reappears, a historical novel written by Zhang Weiqing. It was a story about a transmigrator who assisted Zheng Chenggong in resisting the Qing Dynasty from the end of Ming Dynasty. There was no cheat. The old author's new book was much better than the previous one. The pace was a little slow, but it was very rigorous. It was worth reading.
The Myth of Domination was a fantasy novel written by Qingruojunzi. The main character, Yu Su, traveled between Earth and the other world to collect faith and become the Heavenly Emperor. She was a mastermind, but the part about the other world didn't appeal to me.
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What are the dangers of the liver to drug metabolism?Your statement is wrong. It is the drug that is harmful to the liver metabolism, not the liver that is harmful to the drug metabolism.
The liver was the most important place for the metabolism of drugs in the body. After entering the human body, most drugs needed to be converted into harmless or less toxic substances by the liver before they could play a role in treatment. At the same time, the liver also had to degrade and disinfect the drug metabolism products in order to be discharged from the body. This process required the participation of many kinds of microorganisms in the liver cells. The harm of the drug to the liver was as follows:
1. Long-term or abuse of non-steroid anti-inflammatory drugs and other drugs, in the process of metabolism to produce toxic metabolism products, can lead to liver cell damage and increase the reaction of oxygen stress, resulting in liver damage.
2. Overuse of liver-protecting drugs will increase the burden on the liver due to the metabolism of the drugs in the liver, and may even lead to drug-induced liver injury. Drug interactions may also occur, increasing side effects, affecting the efficacy and safety, and increasing the economic burden of the patient.
3. When the dosage was too large, the medication was used for too long, and the liver function was not complete, any drug would increase the burden on the liver, causing bile discharge, hepatic steatosis, hepatic cell necrosis, hepatic vasodilacy, etc. If the injury repeated, it could cause liver Cirrus, and a few even liver cell cancer.
4. Some drugs, such as acetainide drugs (including fenacetin, parkinson, etc.), can cause liver damage, coagulation disorder and other poisoning phenomena when used in large quantities or accidentally.
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What are the effects of liver metabolism on drugs?The liver had the functions of digesting drugs, decomposing toxins, and synthesizing new substances. The effects of liver metabolism on drugs were mainly reflected in the following aspects:
1. When the liver function was normal, the drug's metabolism ability in the body was stronger. After the drug was digested by the liver, it would be decomposed or secreted, and the drug effect would fade faster. When the liver function was damaged, the drug's metabolism speed in the body would decrease significantly, and the drug would accumulate in the body, resulting in increased drug effect and side effects.
2. There was a two-way relationship between liver malfunction and drug metabolism. On the one hand, drugs would affect the metabolism of the liver and may cause liver damage; on the other hand, adverse liver function would affect the metabolism speed of drugs, prolong the half-life of drugs, and lead to the accumulation of toxic substances in the body, further increasing the burden on liver function, forming a vicious cycle.
3. From the perspective of drug dosage, for example, for people who drink a small amount of alcohol to increase the activity of liver zymes, the metabolism of anesthetic drugs in the liver will be accelerated, and the dosage will increase. For patients who drink too much for a long time, the metabolism of drugs is slow, and the dosage of anesthetic drugs needs to be appropriately reduced.
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The basis for the classification of the metabolism types of microorganisms isThe metabolism types of microorganisms were categorized as follows:
1. ** According to the type of energy transfer and biochemical reaction **: It can be divided into catabolism and anabolism. Catabolization was the process of complex organic molecules producing simple molecules, energy in the form of adenine triphosphorus (ATP-like), and reducing power through the catabolization of the catabolizing system, such as the formation of protein into an ammo acid. Anabolization was the process of synthesizing complex molecules from simple small molecules, energy in the form of ATP-like energy, and reducing power under the catabolizing system. The small molecules were derived from the intermediate products of catabolization or the small molecular nutrients in the environment.
2. ** According to the role of the metabolism in the body **: It can be divided into primary metabolism and secondary metabolism. Primary metabolism provides energy, precursor, structural substances, and other essential metabolism for life activities, and its products are the following types: aa, nt, zymes, and cozymes. Secondary metabolism is the type of metabolism that appears in a certain growth stage and is essential for non-life activities, and its products are antibiotics, colors, hormones, alkaloids, toxins, and vitamins.
3. [According to the purpose of metabolism: It can be divided into material metabolism and energy metabolism.] Material metabolism was the process of transforming substances in the body, and energy metabolism was the mutual transformation of energy forms that accompanied the transformation of substances.
4. ** According to the utilization method of energy source and carbon source in the metabolism process of microorganisms **: It can be divided into photoautotrophy and photoheterotrophy. The photoautotroph type was like photosynthesizing bacteria, cyanobia (water as a hydrogen donor), purple sulfur bacteria, and green sulfur bacteria (H2S as a hydrogen donor, strictly anabolical); the photoheterotroph type used light as an energy source, and organic matter (formated acid, aceticated acid, butyric acid, methanoi, propan, methyruvic acid, and actic acid) as a carbon source and a hydrogen donor to photosynthesize.
5. ** According to the physical state of the medium and the demand for oxygen during the fermentation process, as well as the products produced (for the type of fermentation)**: According to the physical state of the medium, it can be divided into liquid fermentation and solid fermentation; according to the demand for oxygen, it can be divided into two types: fermentation (such as alcohol fermentation, fermentation of yogurt) and fermentation (such as fermentation of antibiotics, fermentation of the acids); according to the products produced, it can be divided into fermentation of antibiotics, fermentation of vitamins, fermentation of the acids, etc.
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Is there any medicine to increase the speed of metabolism?The drugs such as thyroxine tablets, levothyroxine tablets, androgens (such as methylosterone), and the hormone assimilation drugs such as nandrolone could increase the metabolism rate. Thyroxine tablets and levothyroxine tablets were mainly used to treat hypofunction caused by low metabolism. Androgen drugs were mainly used to treat low metabolism caused by iron deficiency. Anabolic hormones such as nandrolone could improve the body's life function, but athletes could not use them. However, unless you follow the doctor's advice, you usually can't use drugs that increase metabolism on your own, because it can easily cause the body's metabolism to be chaotic, and you may also have symptoms such as palpitation, sweating, fear of heat, and weight loss.
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What are the drugs that promote iron metabolism?The following are some drugs or substances related to promoting iron metabolism:
- When taking oral iron, taking vitamins C at the same time can promote iron absorption. You can get vitamins C by eating tomatoes, oranges, kiwifruit and other foods.
- Citric acid and/or citrates can be used to prepare an iron metabolism improver for patients with chronic kidney failure who have epoitin-resistant leukemia (it can be in the form of a disinfectant, in which it does not contain acetate-acid and/or acetate-acid, but contains citrate-acid and/or citrate-acid, and can also contain other vitamins and glucose alone or in combination).
- Commonly used iron agents, such as Ferrous Sulphate, Iron Polyose Complex, Iron Succinate, Ferrous Fumarate, Ferrous Succinate, Ferrous Gluconate, etc. Iron supplements can help to improve the status of iron metabolism.
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