I think it is. The world-building and characters are well-developed. The plot keeps you engaged throughout. But it might not be for everyone, depending on your taste in manga.
Well, it could be that the manga has deep character development or explores themes in a thought-provoking way that makes blaming it unjustified. Maybe the issues people might have with it are more about personal preferences than actual flaws in the work itself.
The Blame manga and its anime adaptation have some similarities, but also differences. The anime tries to capture the essence of the manga but might make some adjustments for visual and narrative flow.
One main plot point is Killy's search for the 'Net Terminal Genes'. Another is his battles with the various dangerous creatures in the megastructures. Also, the exploration of the different zones within this post - apocalyptic world.