Well, in manga, a common way could be to have a serious face-to-face talk in a quiet place. Another option could be to send a message if it's too hard to do it in person. But it's important to be honest and clear about your intentions.
It could be that one character realizes they have grown in a different direction and gently expresses this to the other. Or, an external event could force them to see that their relationship isn't sustainable, but they handle it with maturity and kindness.
" After the Cold Beauty Breaks Up, the Crazy Big Boss's Eyes Turn Red " was a romance novel with a good plot and writing style. The plot was full of ups and downs, and it was exciting. It told the story of the crazy boss's eyes turning red after the cold beauty broke up. This novel was excellent in both style and plot, suitable for readers who liked romance novels.