I don't think so. Comic Thanos has access to cosmic powers and strategies that could pose a serious challenge for Goku. His intelligence and the extent of his powers might be too much for Goku to overcome.
Honestly, comparing the strength of anime Goku and manga Goku is tricky. Both versions have their unique strengths and challenges depicted differently, making it hard to make a clear-cut comparison.
Well, Vegeta would be a likely character. He might be initially suspicious of the female Goku. Maybe he thinks she's a threat or just can't believe there's another Goku - like being. He could be there to add some comical moments as he tries to understand the situation.