In my opinion, it's highly unlikely. Goku has mastered multiple forms and techniques that give him a wide range of powers. Saitama's one-punch style might not be effective against Goku's diverse skills and battle experience.
I don't think there's a clear winner. Both Manga Goku and Manga Saitama have unique and powerful abilities. It could come down to strategy, luck, or even the author's imagination!
In the manga, Gohan never managed to defeat Goku. Their battles often ended with Goku coming out on top or the fight being interrupted for some reason.
Goku's victory over Hit in the manga was the result of his perseverance and the ability to surprise Hit with unexpected moves. Also, his experience in battles played a significant role.
Wu Zhu was a powerful character in " Celebrating Years." He remained undefeated in his fight with Hong Sixiang and successfully concealed his strength. In addition, there were other search results that mentioned that Wu Zhu could easily defeat a Rank-8 expert, and that when facing more than ten Rank-8 experts, it only took less than five minutes. Although there was no clear mention of who could defeat Wu Zhu, according to the description in the search results, Wu Zhu was very powerful. He had fought fiercely with the Qing Emperor and other Great Grandmasters, and both sides suffered. Therefore, according to the information provided, there was currently no clear answer to who could defeat Wu Zhu.