Garou from OPM might also work well. His ideology of being a 'human monster' and his constantly evolving strength could make him a formidable foe for Saitama. Their clash could be not only about physical strength but also about their different views on what it means to be a hero or a monster.
Another interesting concept is a crossover where the villains from the OPM world are a threat to Saitama's own world. Saitama then has to team up with the OPM heroes to fight back. This could lead to some really cool fight scenes and interactions between different characters.
It depends on your preferences. If you like action-packed and unique superhero concepts, OPM might be for you. But if you're into divine and mythical themes, God manga could be the choice.
Saitama would win. He has shown incredible strength with just one punch. His power seems limitless, and in a fanfiction scenario, his simplicity and raw power would likely overpower Jiren's more complex abilities.
One possible plot twist could be that Jiren discovers a way to nullify Saitama's strength. Maybe he finds some sort of energy - draining technique that weakens Saitama over time. Another could be that Saitama holds back for some reason, like he wants to see the full extent of Jiren's power, and in doing so, he gets into a real struggle.
In a Saitama vs OC fanfiction, a plot twist could be that the OC has the power to make Saitama lose his strength. However, the OC doesn't want to use this power because they admire Saitama and want to test their own strength against him fairly. Another interesting twist could be that the OC is a part of a bigger plan by some mysterious organization. They use the fight against Saitama as a distraction while they carry out their real objective elsewhere. And as the fight progresses, Saitama realizes this and has to decide whether to continue the fight or go after the real threat.
Well, it really depends on how the OC (Original Character) is designed. If the OC has some really unique and powerful abilities that can counter Saitama's strength, like the ability to nullify physical attacks or something really out - of - the - box, then the OC might stand a chance. But Saitama is known for his one - punch knockout power. So, in most cases, Saitama would probably win due to his overwhelming strength that has defeated almost every foe he's faced so far.