bioisostere replacement success stories

A great example is in the development of statins. Lovastatin was one of the first statins. Through bioisostere replacement, atorvastatin was created. Atorvastatin has a different chemical moiety due to bioisostere substitution, which gives it better lipid - lowering properties and a longer half - life. This allows for once - daily dosing, which is more convenient for patients.

One success story is the replacement in angiotensin - converting enzyme (ACE) inhibitors. By using bioisostere replacement, new drugs with better selectivity and fewer side effects were developed. For example, enalapril was developed through bioisostere modification of captopril. This led to improved pharmacokinetic properties and better patient compliance.

Yes, there are many. For example, my friend had a neck disc replacement. Before the surgery, he suffered from severe neck pain that limited his daily activities. After the successful replacement, his pain reduced significantly and he was able to return to his normal life, including going back to work and resuming his hobbies like cycling.

My grandpa had a knee replacement. Before the surgery, he could barely walk. Afterward, he gradually regained his mobility. Now he can take short walks in the park and even climb stairs with ease. It's been a great success for him.

A transgender woman had a very positive experience with hormone replacement therapy. It helped her develop more feminine physical characteristics, like softer skin and breast growth. Emotionally, it also had a huge impact. She felt more in tune with her true self. It gave her the confidence to be more open about her identity and to fully participate in society as the person she knew she was.

Post - surgery care is a big part. This includes proper physical therapy. I know someone who had knee replacement. They followed the physical therapy plan strictly and recovered well. Also, a positive attitude of the patient helps a lot. They need to be patient during the recovery process.

A woman who had ankle pain for a long time had ankle replacement. After that, she no longer needed painkillers. Her ankle was stable and she could stand for long periods without pain.

There are success stories regarding mood improvement as well. Men who were previously irritable or in a low - mood state often become more positive. Consider a man who was always grumpy and withdrawn. After testosterone replacement therapy, he became more sociable and his family noticed a big change in his attitude. And for some, bone density also improves, reducing the risk of fractures in the long run.

Well, proper hydration is important in these success stories. When you're on a meal replacement diet, your body still needs water to function well. Also, having a support system helps. Some people join groups or have friends who are also on the diet, which keeps them motivated. Exercise also plays a role. Even light exercise like walking while on a meal replacement diet can enhance the results.

My neighbor had knee replacement surgery. After it, he could walk his dog again. Simple as it may seem, before the surgery, his knee pain made this a near - impossible task. It was a great success for him.