Well, it could start with Ash being transformed into a Pikachu in a mysterious forest. His friends are initially confused but soon realize it's him. As a Pikachu, Ash discovers new abilities he didn't know about before. He might be able to sense things like incoming danger more acutely. He could also have a hard time convincing his other Pokémon that he is still their trainer. Throughout the fanfiction, there could be a series of comical and exciting events as he tries to adapt to his new form and find a way to reverse the transformation.
His friends would be very shocked at first. Misty might be a bit worried and try to find a way to turn him back quickly. Brock, on the other hand, would be more curious and start observing Ash - as - Pikachu to see how his behavior has changed. His Pokémon friends would also be confused. Pikachu himself might be both excited to have a 'Pikachu - like' friend but also a bit sad that his trainer is in this strange state.
Most likely, this is a very niche and perhaps even inappropriate concept for fanfiction. The Pokémon world and the human world are kept quite distinct in the official lore, and crossing those boundaries in such a way as a 'pregnant' scenario goes against the general spirit of the Pokémon franchise. So, it's doubtful there are many, if any, proper fanfictions on this.
Well, one possible interpretation could be a very strange and unique take on the relationship between Ash and Pikachu. Maybe it's a metaphorical exploration of their deep bond in a really extreme way. But this is a very odd concept.
The human would probably be extremely confused at first. Suddenly having a different body, with four legs and a tail, and seeing the world from a much lower perspective would be disorienting.
One possible plot could be Sonic accidentally getting hit by a strange energy beam during a battle with Dr. Eggman. This beam could have some sort of mutagenic effect that slowly starts to transform him into a human. As he turns into a human, he has to deal with the loss of his super speed at first. He then has to adapt to living as a human while still trying to protect his friends and the world from Eggman's new threats.
No, in the real world, there's no way for a Pikachu and a human to get pregnant. Fanfiction, especially the 'lemon' variety, sometimes takes very wild and unorthodox ideas. But we need to remember that it's all fictional and often not in line with common sense, biology, or ethical standards. This kind of fanfiction might be written for shock value or to explore very extreme and often inappropriate ideas within a fictional and often unregulated writing space.
One way to develop it could be through a magical encounter. Maybe the human stumbles upon an ancient relic in a forgotten cave. This relic releases a strange energy that slowly starts to transform the human into Nergigante. As the transformation progresses, the human begins to experience new instincts and powers related to the fearsome beast.
Dr. Eggman would be an obvious choice. Since Sonic is now in a more vulnerable human form, Eggman could see this as the perfect opportunity to finally defeat Sonic and take over the world. He might come up with new devious plans, like creating robots specifically designed to target a human Sonic.
One popular story could be about a young girl who, through a magical accident, starts to transform into an alicorn. She discovers new powers like flight and magic as she goes through this change, and has to learn to adapt to her new form while hiding it from the non - magical world.