The fem Kyuubi might feel a sense of protectiveness. Seeing Naruto without his mask could make her realize how vulnerable he is. She may then use her powers to safeguard him from any potential threats that could take advantage of his exposed state.
In such a scenario, his relationships would be severely affected. His friends would be horrified by the change in him. Naruto's bond with Sasuke, for example, would be in jeopardy. Since he has lost his humanity, he may not understand the concept of friendship anymore and might even see Sasuke as a rival to be eliminated. And his relationship with the female Kyuubi would be complex. Maybe she would try to control him or use his new state for her own purposes.
One possible plot could be that Naruto's loss of sanity causes him to have a distorted view of the Fem Kyuubi. Maybe he sees her as both a threat and a source of power he can't control. This could lead to a conflict within himself as he battles his inner demons while also interacting with the Fem Kyuubi in unexpected ways. For example, instead of the usual relationship of cooperation or taming, he might try to completely dominate her, which would be a big shift from the normal Naruto we know.
Other characters in the Naruto universe might also be affected. For example, his friends like Sakura and Kakashi would notice the change in Naruto. They might try to help him, but their attempts could be in vain because of the complex situation with the Fem Kyuubi involved. This would create new tensions and storylines as they struggle to deal with a Naruto who has lost his sanity and the mystery of the Fem Kyuubi's role in it.
If Naruto loses his mask in this fanfiction, it might change the power dynamics. His identity being more exposed could make him a target. The fem Kyuubi might have to step up and use her powers to protect him. This could lead to a closer bond between them, and they might start to rely on each other more in the face of new threats.
Maybe he loses his humanity as a result of a failed experiment. Some rogue ninja or a secret organization might try to enhance his power but end up corrupting his very essence. As a consequence, Naruto could start to show no mercy, lack empathy, and use his powers for destruction rather than protection.
One great fem Naruto x fem Kyuubi fanfiction could be one that focuses on their unique bond. It might explore how they interact in a world where Naruto is female and the Kyuubi also takes a female form. For example, it could show them teaming up against common enemies and how their combined powers are different from the original story.
A new and mysterious dark ninja could be the main antagonist. This character might have a special ability to corrupt others. They target Naruto specifically because of his power and influence. By using some form of dark jutsu or psychological manipulation, they make Naruto lose his humanity, turning him into a weapon against the very people he used to protect.
If the Kyuubi loses its memory in the fanfiction, it could potentially change the entire Naruto storyline. For instance, Naruto may no longer have the same source of power that he once had. Instead, he might have to rely on his own natural talents and training more than ever. The Kyuubi, without its memories, could start to develop a new personality. It might become more curious and innocent, which would be a huge contrast to its previous menacing self. This would force Naruto to adapt and also give the other characters in the series new ways to interact with both Naruto and the Kyuubi.