The plot could be that Minato is brought back to life by some dark jutsu gone wrong. Sakura, being a skilled medical ninja, tries to find a way to reverse the effects while they are both on the run from those who want to use Minato's power. Along the way, they form an unlikely bond and learn from each other.
One great fanfiction could be where Sakura discovers some of Minato's old jutsu notes and tries to learn from them. This could lead to her developing new skills and also a connection to Minato's legacy in the ninja world.
Another idea is that the OC is from a far - off land and comes to Konoha for medical training. Sakura is assigned to be their mentor. At first, they clash because of their different cultural backgrounds and ways of thinking. But as they spend more time together in the hospital, they start to understand each other better and feelings begin to develop.
Bashing Sakura can also add a new layer of conflict. If the fanfiction is set in the Naruto universe where Sakura is a respected ninja, making her into an antagonist towards Itachi and Naruto can create a whole new plotline. It could be about Itachi and Naruto having to overcome Sakura's schemes or bad attitude. However, this does change the original feel of the Naruto world quite a bit.
Since it's fanfiction, the possibilities are endless. It could be that in this story, Naruto Namikaze and Hana are from different clans but find common ground. They might have to work together to save their village or something bigger. It could also be a story that focuses on their personal growth, with each other's influence playing a significant role. For example, Naruto Namikaze's positive attitude might inspire Hana, and Hana's skills could help Naruto Namikaze in tough situations.
There is a fanfiction where Naruto and Sakura time - travel back to the founding of Konoha. They use their modern - day knowledge and skills to help the early shinobi, and during this adventure, their relationship blossoms as they work side by side. It shows a different side of their dynamic as they interact with the founders of the village.
Well, a frequently seen theme is the exploration of their individual powers. Sakura's medical ninjutsu and Naruto's various ninja techniques are often developed further in fanfictions. Their relationship with other characters in the Naruto universe also serves as a common theme. And of course, the theme of facing and defeating powerful enemies together is quite popular.
Some people might find the appeal in exploring different relationship dynamics. By bashing Sakura in an Itachi x Naruto fanfiction, it could be a way to remove what they see as a potential obstacle to the Itachi - Naruto relationship. They might want to focus solely on the connection between Itachi and Naruto without the complication of Sakura's character. However, this often involves a misrepresentation of Sakura's character as she has her own strengths and development in the original series.
One idea could be Naruto and Sakura Namikaze going on a mission together to a far - off land. They encounter strange creatures and have to use their combined skills to survive. Another could be a story where they time - travel back to the early days of Konoha and have to prevent a major disaster from happening.
Sasuke would be a great secondary character. His complex relationship with Naruto and Sakura could add a lot of drama. Kakashi too, as he can be a mentor figure to them. And Shikamaru, with his intelligence, can help them out in difficult situations.