Maybe the story focuses on Naruto's search for his vampire heritage. He could be on a journey to find out more about his mother, the queen vampire. Along the way, he meets other supernatural beings who either help or hinder him. His friends from the ninja world, like Sasuke and Sakura, might initially be in the dark about his true nature but gradually come to understand and support him.
Obviously, there would be the queen vampire, his mother. She could be a powerful and mysterious figure, perhaps with her own motives and plans for Naruto. There might also be some vampire elders or nobles who play a role in Naruto's life, either guiding him or trying to use him for their own purposes.
Obviously Naruto himself and Queen Celestia as his mother. There could also be characters from the Naruto series like Sasuke and Sakura. They might come to the world where Queen Celestia rules to help Naruto or to explore. And from Queen Celestia's side, there could be her loyal subjects, like the ponies if it's related to the My Little Pony world where she is from. They could interact with Naruto in various ways, either being friendly or a bit suspicious of this new 'son' of their queen.
The plot might involve Naruto having to prove himself as the son of Queen Celestia. There could be those who doubt his lineage and he has to go on quests or battles to show that he is worthy. He could also learn about his mother's (Queen Celestia) history and the secrets of the land she rules, all while using his ninja skills in a new and magical context.
One storyline could be Naruto growing up in the Naruto world but having strange dreams and powers that he doesn't understand. As he gets older, he discovers his true heritage as the son of Queen Serenity. This leads to him having to travel to the Sailor Moon world to learn about his mother's legacy and gain control over his new - found powers.
Maybe a dark ninja clan that has a grudge against Naruto and also wants to control the Vampire Queen for her powers. They would try to set traps for both Naruto and the Queen, making it difficult for them to trust each other and work together against the real threat.
Well, perhaps the Vampire Queen is cursed and Naruto, with his kind heart, decides to help her break the curse. In the process, they have to face many challenges together. Naruto's ninja skills and the Queen's vampiric abilities complement each other as they fight against dark forces that are trying to keep the curse in place. As they spend more time together, they start to understand each other's worlds better and a bond forms between them.
Naruto would likely be more refined in his manners. Since he's the son of a queen, he'd probably grow up with a certain level of etiquette. But he'd still keep his core values of never giving up and protecting his friends.
Well, one way this could work is through some sort of multiverse or time - travel concept. Maybe in a different dimension, Naruto's origin is linked to Queen Serenity. For example, a powerful magic or jutsu could have accidentally connected their worlds, and Naruto could inherit some of the Queen's powers, like the ability to control the Silver Crystal in a new form related to chakra.
One plot idea could be that Naruto, as the son of a queen, has to deal with the political intrigue in the hidden villages. He might use his unique position to try and bring about peace between the different ninja clans. Another could be that his mother, the queen, was from a far - off land and Naruto has to discover his heritage there while also facing challenges from local powers.