Betrayal is a huge theme. His friends, his sensei, or the villagers might betray him for various reasons, and Naruto has to deal with that heartbreak. There's also the theme of transformation. The pain of being hurt by everyone can transform Naruto into a more hardened or wiser person. Additionally, the theme of forgiveness may come into play. Naruto may have to decide whether to forgive those who have caused him so much pain or hold a grudge.
One possible storyline could be that Naruto is wrongly accused of a serious crime in the village. Everyone turns against him, even his friends. He might be shunned and face physical attacks from villagers who once feared or respected him. Naruto would then have to struggle to prove his innocence while dealing with the emotional pain of being betrayed by those he cared about.
Naruto might be hurt by fanfiction in various ways. For example, some fanfictions could distort his character. They might portray him as overly cruel or weak, which goes against his original essence in the official story. This can mislead fans who are new to the Naruto universe and create a wrong perception of him.
It could be that Anko is under some sort of mind - control in the fanfiction. And because of that, she attacks Naruto without really meaning to. Maybe she has been influenced by an enemy's genjutsu. So, she uses her powerful attacks on Naruto, and he gets hurt as a result.
One consequence could be an imbalance in the world's population. There might be too many people for the existing resources, leading to shortages of food, water, and living space.
It could be that his new 'godlike' power has isolated him. People might be either in awe or afraid of him, and he may feel that he can't be close to others as before. So he acts coldly as a defense mechanism.
Maybe she's jealous of Naruto's popularity or his strength. It's possible that she feels overshadowed by him all the time and that jealousy turns into resentment, leading her to hurt Naruto.
There are various scenarios that could play out in such a fanfiction. Maybe Naruto was injured during a mission and Kiba stumbles upon him in the forest. Kiba would then likely try to help Naruto, either by getting medical help or using his own skills if he has some knowledge of healing. This could lead to a deeper bond between them as Kiba shows his concern and Naruto is grateful for the assistance.
Well, in some fanfictions, Naruto might use some super powerful jutsu that he either discovers or creates. Maybe it's a new form of the Rasengan combined with some sealing techniques. It could also be that he taps into some ancient power or makes a deal with some sort of god - like entity within the Naruto universe.
Maybe he got some kind of curse. In the Naruto universe, there are all sorts of dark magic and curses. If he was cursed, it could make him withdrawn and cause him to ignore everyone.