No way. 'House of the Spirits' is fictional. It creates a fictional world with its own unique plot and characters, rather than being based on real-life events or people.
Well, I think the themes of fate and memory are prominent in 'The House of the Spirits'. The characters seem to be guided by a sense of fate, and their memories shape their actions and relationships. Also, the theme of social change is there. The novel depicts how society changes over time and how the characters are affected by it.
One of the main themes is family. The family's history, relationships, and secrets play a significant role in the story. Another is political unrest as it is often set against a backdrop of political change. Also, the theme of magic realism is prominent, with spirits and supernatural elements being an integral part of the narrative.