The relationship between Konoha and the Uzumaki clan might be further strained. With Kushina leaving, Konoha would lose an important link to the Uzumaki. And other Uzumaki members might see this as a sign that Konoha is not a safe place for them.
One possible reason could be for Naruto's safety. Maybe she has to go on a dangerous mission and believes Konoha is the safest place for him. Another reason might be that she is forced by some powerful enemies who threaten Naruto's life if she doesn't leave him in Konoha.
One possible reason could be to protect Naruto from the hidden threats in Konoha. Maybe she discovers some dark secrets or plots within the village that she believes will endanger Naruto, so she decides to take him away.
In a 'naruto and kushina leaves konoha fanfic', perhaps they leave due to a threat to Naruto's safety that the village can't fully protect against. Maybe some secret organization is after him and they feel they have no choice but to go into hiding outside Konoha.
Naruto would probably feel abandoned at first. He might become more withdrawn and have trust issues. But as time goes on, he could grow stronger out of a need to prove himself. He may also form closer bonds with his friends in Konoha, like Sasuke and Sakura, as they become his new family in a way.
He may face some difficulties in understanding his identity. Since Kushina is not there to tell him about his family background, he might have to discover it on his own, which could lead to some misunderstandings and challenges. Also, his relationships with other characters in Konoha could be different. For example, he might seek more father - like figures among the villagers, which could change the dynamics of his interactions with them.
In Naruto fanfiction, a Kushina mind - wipe in Konoha could lead to some really interesting plot twists. Maybe it could be part of a scheme by an enemy to disrupt Naruto's life further. Since Kushina was Naruto's mother, her having a mind - wipe would change the dynamics of how Naruto discovers his family history and heritage.
Konoha would initially be in shock. Naruto is a hero to many in the village, and his sudden departure with Itachi, who was once considered a traitor, would cause a lot of unrest. The villagers might start to question the leadership of the village, wondering why Naruto left and if there was something they could have done to prevent it.
Another reason could be that he witnesses corruption or unfairness within the village leadership. If he sees that the system is rigged against certain groups, including himself or his friends, he could grow to hate Konoha and decide to leave.
One possible reason could be for his safety. Konoha is a well - protected village with many skilled ninja. She might believe that leaving him there would ensure he has the best chance at survival and growth as a ninja. Also, she may have some mission or obligation that forces her to leave him behind, perhaps something related to the greater good of the village or the ninja world in general.