In fanfictions, Naruto could run away from his family due to emotional abuse. If his family members constantly put him down, criticize his abilities, or make him feel unworthy, he'd likely want to escape. Also, if his family is involved in some political intrigue that he doesn't want to be dragged into. For instance, they might be making deals with other clans that Naruto disagrees with. Additionally, if there is a new family member introduced, like a step - sibling who is favored over him and he feels unloved, that could prompt him to run away.
One possible reason could be fear. Minato is a very powerful shinobi, and Naruto might be scared of him for some reason. Maybe he has heard stories about Minato that made him afraid.
Perhaps Naruto discovers something about Itachi that the rest of the world doesn't know and he needs to run away to protect that secret. It could be a powerful jutsu or a message that could change the balance of power in the ninja world.
Maybe he feels misunderstood by his family. In many Naruto stories, his family situation can be complex. If he's 'godlike', he might have powers that his family doesn't understand or fears, leading him to run away to avoid conflict or being treated differently.
Perhaps he is running away from danger in Konoha. There could be a threat that he believes he can't face directly in the village, and he thinks Whirlpool might offer some sort of sanctuary or a way to become stronger in relative safety.
Maybe he's running away from some kind of danger or threat in his home village. There could be a group or an individual after him, and he believes that Kumo would be a safer place. It could also be related to some political unrest in Konoha that makes him feel like he has to leave, and Kumo seems like a viable option.
Maybe he's running away from the pressure in the village. There are always high expectations on him, and he might feel suffocated and need some time alone to figure things out.
Another reason could be that she wants to explore the world on her own terms. In the fanfiction, Mirabel may be tired of always being in the family's protective bubble. She desires to see what lies beyond the village and the mountains, so she runs away to start her own adventure.
There are several possible reasons. Firstly, a sense of being controlled. If Edward is constantly making decisions for her or restricting her actions, Bella would want to break free. Secondly, self - preservation. If she realizes that the relationship is putting her in more danger than she can handle, she'll run. Thirdly, a change in her feelings. Maybe she falls out of love with Edward or realizes she was never truly in love, but rather in some sort of infatuation. So, she runs away to sort out her emotions and her life.
Another reason could be related to a prophecy or a hidden mission. They might have learned about a prophecy that required them to leave Konoha in order to fulfill it. This could involve finding a powerful artifact or learning a special technique that could only be achieved by being away from the village. Their departure would then be a sacrifice for the greater good of not just Konoha, but the entire ninja world.
Perhaps Naruto feels that Kushina is being overprotective. He wants to prove his independence and go on his own adventures without her constant supervision, so he decides to run away.