It could be due to some misunderstanding. For example, if he's wrongly accused of something he didn't do, like being suspected of a crime in the village. Naruto is impulsive sometimes, and instead of trying to clear his name right away, he might just choose to run away until he can prove his innocence in a better way.
Maybe he's running away from the pressure in the village. There are always high expectations on him, and he might feel suffocated and need some time alone to figure things out.
Maybe he feels misunderstood by his family. In many Naruto stories, his family situation can be complex. If he's 'godlike', he might have powers that his family doesn't understand or fears, leading him to run away to avoid conflict or being treated differently.
Perhaps Naruto feels that Kushina is being overprotective. He wants to prove his independence and go on his own adventures without her constant supervision, so he decides to run away.
One possible reason could be that Naruto might be afraid of the intense training Jiraiya has in store for him. Jiraiya is known for his strict and grueling training methods, and Naruto, being young and sometimes impatient, might just want to escape that for a while.
They might run away to avoid a conflict that their villages are about to be dragged into. Naruto and Sasuke, being the powerful ninjas they are, don't want to be used as tools in a war, so they decide to run away.
Perhaps he is running away from danger in Konoha. There could be a threat that he believes he can't face directly in the village, and he thinks Whirlpool might offer some sort of sanctuary or a way to become stronger in relative safety.
Maybe he's running away from some kind of danger or threat in his home village. There could be a group or an individual after him, and he believes that Kumo would be a safer place. It could also be related to some political unrest in Konoha that makes him feel like he has to leave, and Kumo seems like a viable option.
One possible reason could be fear. Minato is a very powerful shinobi, and Naruto might be scared of him for some reason. Maybe he has heard stories about Minato that made him afraid.
Love. Naruto may finally realize his true feelings for Hinata and want to be away from the chaos of the village to be with her in peace.
One consequence could be that his friends worry about him a great deal. They might go on a search for him, which could put them in danger as well. After all, they care about Naruto deeply and won't just let him disappear without trying to find him.
He could run to the Land of Waves. He has a connection there from his early mission. The people there were friendly to him, and he might find some peace and acceptance among them. It's a place where he could start anew, away from the chaos of Konoha.